某些天然前列腺素对离体人环状支气管肌的作用。

The effects of some natural prostaglandins on isolated human circular bronchial muscle.

作者信息

Gardiner P J

出版信息

Prostaglandins. 1975 Oct;10(4):607-16. doi: 10.1016/s0090-6980(75)80007-4.

PMID:1197790

Abstract

PGE1 relaxed isolated human circular bronchial muscle over a wide concentration range as did isoprenaline. Surprisingly isoprenaline was more potent than PGE1. PGF2alpha weakly contracted this muscle preparation whereas histamine was more potent. PGE2, however, produced paradoxical results, relaxing some tissues and contracting others, always in a concentration-related manner irrespective of tissue tone. In preparations that contracted to PGE2, tachyphylaxis induced to PGF2alpha also applied to PGE2, but did not affect PGE1 relaxations of histamine contractions. These findings suggest that pge2 can stimulate either PGF2alpha or PGE1 receptors of isolated human bronchial muscle.

摘要

前列腺素E1（PGE1）在很宽的浓度范围内均可使离体人环形支气管肌松弛，异丙肾上腺素也有同样作用。令人惊讶的是，异丙肾上腺素比PGE1的作用更强。前列腺素F2α（PGF2α）使该肌肉标本轻度收缩，而组胺的作用更强。然而，PGE2产生了矛盾的结果，它使一些组织松弛而使另一些组织收缩，且总是以浓度相关的方式，与组织张力无关。在对PGE2产生收缩反应的标本中，对PGF2α产生的快速耐受也适用于PGE2，但不影响PGE1对组胺收缩反应的松弛作用。这些发现提示，PGE2可刺激离体人支气管肌的PGF2α或PGE1受体。