大鼠气管、支气管和肺条离体标本上药物诱导反应的比较。
A comparison of drug-induced responses on rat tracheal, bronchial and lung strip in vitro preparations.
作者信息
Burns J W, Doe J E
出版信息
Br J Pharmacol. 1978 Sep;64(1):71-4. doi: 10.1111/j.1476-5381.1978.tb08642.x.
Abstract
- A preparation of rat trachea and a new preparation of rat bronchi are described. Both preparations are fluid-filled and the intraluminal pressure is monitored. 2. A preparation of rat peripheral airways, the lung strip, is described. The preparation consists of a thin strip of lung parenchyma which is superfused, and contractions monitored isotonically. 3. The rat trachea and bronchi have no intrinsic tone but increases in pressure are elicited in response to methacholine. The preparations relax in response to isoprenaline and aminophylline in the presence of a methacholine-induced contraction. Both preparations respond weakly and show tachyphylaxis to 5-hydroxytryptamine (5HT). 4. The lung strip contracts with equal magnitude to methacholine and 5-HT. It exhibits intrinsic tone which is inhibited by indomethacin and relaxed by isoprenaline.
摘要
- 本文描述了大鼠气管的一种制备方法以及大鼠支气管的一种新制备方法。两种制备物均充满液体，并监测腔内压力。2. 本文描述了大鼠外周气道的一种制备方法，即肺条。该制备物由一条薄的肺实质条组成，对其进行 superfused，并等张监测收缩情况。3. 大鼠气管和支气管没有内在张力，但对乙酰甲胆碱有压力增加反应。在乙酰甲胆碱诱导的收缩存在的情况下，制备物对异丙肾上腺素和氨茶碱有松弛反应。两种制备物对 5-羟色胺（5HT）反应较弱且出现快速耐受性。4. 肺条对乙酰甲胆碱和 5-HT 的收缩幅度相同。它表现出内在张力，该张力被吲哚美辛抑制，被异丙肾上腺素松弛。 （注：“superfused”此处原文可能有误，推测可能是“superfused”，意为“灌流” ）
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