Lindbom Lennart, Werr Joachim
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, S-171 77, Sweden.
Semin Immunol. 2002 Apr;14(2):115-21. doi: 10.1006/smim.2001.0348.
Leukocyte recruitment to sites of injury or infection involves sequential interactions with endothelium and extravascular tissue components. While the intravascular events in this process have been extensively studied, the mechanisms regulating subsequent passage through the surrounding tissue are less well characterized. The migrating white blood cells need to establish transient and dynamic adhesive contacts with extracellular matrix proteins. Integrin receptors expressed on the leukocyte surface play a central role in these interactions, mediating linkages between the cytoskeloton and the external environment. This chapter focuses on roles of integrin molecules in neutrophil locomotion and the adhesive mechanisms that govern the motility of these cells in the extravascular tissue.
白细胞募集到损伤或感染部位涉及与内皮细胞和血管外组织成分的一系列相互作用。虽然这一过程中的血管内事件已得到广泛研究，但调节随后穿过周围组织的机制却不太清楚。迁移的白细胞需要与细胞外基质蛋白建立短暂而动态的粘附接触。白细胞表面表达的整合素受体在这些相互作用中起核心作用，介导细胞骨架与外部环境之间的联系。本章重点讨论整合素分子在中性粒细胞运动中的作用以及控制这些细胞在血管外组织中运动的粘附机制。
