Abelmann W H, Adesanya C O, Goldberg A H, Phear W P, Young N A
Recent Adv Stud Cardiac Struct Metab. 1975;6:535-42.
A model of experimental Coxsackie virus B3 myocarditis has been developed in the weaning Syrian golden hamster. The acute infection is characterized by extensive viral replication in the myocardium, associated with transient myocytolysis and leukocytic infiltration. At 2 weeks after inoculation, there is survival without evidence of cardiac hypertrophy or failure, and minimal residual light microscopic changes. In order to evaluate myocardial function during convalescence form this form of myocarditis, muscle mechanics were studied in left ventricular trabeculae careae in 10 infected and 7 control animals, 18 days after inoculation. Maximum developed tension of the infected animals was depressed by 25%, and there was a significant decrease in the time to peak tension. Furthermore, the infected muscles required less stretch to reach that length at which maximal developed tension was produced. These data indicate that myocardial function remains depressed during early convalescence from acute Coxsackie virus B3 myocarditis and suggest that this state is associated with decreased compliance. Studies of myocardial morphology and function at longer intervals after acute experimental viral myocarditis are indicated, to further test the hypothesis that viral myocarditis might be a precursor chronic isiopathic cardiomyopathy.
在断奶的叙利亚金黄地鼠中建立了实验性柯萨奇病毒B3心肌炎模型。急性感染的特征是心肌中广泛的病毒复制，伴有短暂的心肌细胞溶解和白细胞浸润。接种后2周，动物存活，无心脏肥大或衰竭的迹象，光镜下残留变化极小。为了评估这种心肌炎康复期的心肌功能，在接种后18天，对10只感染动物和7只对照动物的左心室乳头肌进行了肌肉力学研究。感染动物的最大舒张张力降低了25%，达到峰值张力的时间显著缩短。此外，感染的肌肉达到产生最大舒张张力的长度所需的拉伸较小。这些数据表明，急性柯萨奇病毒B3心肌炎早期康复期心肌功能仍受抑制，提示这种状态与顺应性降低有关。有必要对急性实验性病毒性心肌炎后更长时间的心肌形态和功能进行研究，以进一步验证病毒性心肌炎可能是慢性特发性心肌病先兆的假说。
