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[膀胱内卡介苗免疫疗法诱导的粟粒性病变用于膀胱癌:CT表现]

[Miliary induced by intravesical BCG immunotherapy for carcinoma of the bladder: CT Findings].

作者信息

Mignon F, Chevrière A, Mesurolle B, El Hajam M, Morel H, Lacombe P

机构信息

Service de radiologie, Hôpital de Versailles, 78157 Le Chesnay, France.

出版信息

J Radiol. 2002 Mar;83(3):368-71.

Abstract

The authors describe the case of a patient presenting miliary involvement of the lung due to mycobacterium bovis after intravesical BCG administration. After initial transurethral resection, the patient was treated with immunotherapy by intravesical instillation of BCG and received 9 treatments without any problem. After the 10th treatment, the patient presented with cough and signs of urinary infection. At admission the chest radiograph showed a miliary pattern, better seen at high resolution CT, and using helical technique with the maximum intensity projection (MIP) reconstructions. MIP demonstrated to better advantage the well defined contours of the nodules, distributed evenly and randomly in the whole lung. After anti-TB treatment, the patient had regained full activity with persistence of the miliary pattern but a decreased number and size of nodules and calcification in some of them. This case illustrates a rare complication of intravesical immunotherapy, and points out the superiority of Sliding Thin Slab MIP (STS-MIP) compared with standard HRCT which allows a better detection of extent and follow-up of a military pattern, notably in moderate forms, by improvement of the anatomical resolution.

摘要

作者描述了一例膀胱内灌注卡介苗后发生牛分枝杆菌引起的肺部粟粒样病变的患者病例。在最初的经尿道切除术后,患者接受了膀胱内灌注卡介苗的免疫治疗,共进行了9次治疗,未出现任何问题。第10次治疗后,患者出现咳嗽和泌尿系统感染症状。入院时胸部X线片显示粟粒样表现,高分辨率CT(采用螺旋技术及最大密度投影(MIP)重建)显示更佳。MIP更能清晰显示结节轮廓,结节在全肺均匀随机分布。抗结核治疗后,患者恢复了全部活动能力,粟粒样表现持续存在,但结节数量减少、大小缩小,部分结节出现钙化。该病例说明了膀胱内免疫治疗的一种罕见并发症,并指出与标准高分辨率CT相比,滑动薄层MIP(STS-MIP)具有优越性,它能通过提高解剖分辨率更好地检测粟粒样病变的范围并进行随访,尤其在病变程度中等时。

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