Brundin T
Scand J Clin Lab Invest. 1975 Oct;35(6):539-43.
The temperature of mixed venous blood (PA-temp) was measured in the pulmonary artery of healthy male volunteers at rest and during bicycle exercise in the supine position. Oxygen uptake, arteriovenous oxygen difference, and heart rate were determined simultaneously. The subjects were studied both in their basal normokinetic circulatory state and in a hypokinetic circulatory state induced by beta-receptor blockade with propranolol. The PA-temp increased linearly with rising oxygen uptake. During beta-receptor blockade the exercise-induced rise in PA-temp was considerably steeper in relation to work load and to oxygen uptake. Thus when the ordinary ability to increase cardiac output was suppressed by propranolol, an identical dynamic exercise induced a significantly higher PA-temp. A significant correlation (r = 0.92) was found between the rise in PA-temp during exercise and the increase in the arteriovenous oxygen difference. This correlation, which has not been described previously, was not altered by beta-receptor blockade. It is concluded that the close correlation between blood temperature and arteriovenous oxygen difference has a clinical potential for hemodynamic measurements. A simple method for the indirect estimation of arteriovenous oxygen difference by means of blood thermometry would be a considerable laboratory advantage.
在健康男性志愿者处于静息状态及仰卧位进行自行车运动期间，测量其肺动脉内的混合静脉血温度（PA - 温度）。同时测定摄氧量、动静脉氧差和心率。研究对象在基础正常动力循环状态以及用普萘洛尔进行β受体阻断诱导的低动力循环状态下均接受了研究。PA - 温度随摄氧量的增加呈线性升高。在β受体阻断期间，与工作负荷和摄氧量相关的运动诱导的PA - 温度升高明显更陡。因此，当普萘洛尔抑制了增加心输出量的正常能力时，相同的动态运动诱导出明显更高的PA - 温度。运动期间PA - 温度的升高与动静脉氧差的增加之间存在显著相关性（r = 0.92）。这种先前未被描述过的相关性在β受体阻断时并未改变。得出的结论是，血液温度与动静脉氧差之间的密切相关性在血流动力学测量方面具有临床潜力。通过血液温度测量间接估计动静脉氧差的简单方法将是一项相当大的实验室优势。
