WNT信号传导与淋巴细胞发育。
WNT signaling and lymphocyte development.
作者信息
van de Wetering Marc, de Lau Wim, Clevers Hans
机构信息
Department of Immunology, UMC Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
出版信息
Cell. 2002 Apr;109 Suppl:S13-9. doi: 10.1016/s0092-8674(02)00709-2.
Abstract
Developmental studies in model organisms have revealed that cell fate decisions are governed by only a handful of highly conserved signal transduction cascades. Recent data indicate that at least two of these, the Wnt and the Notch cascades, have been recruited by the vertebrate immune system to control early lymphopoiesis.
摘要
对模式生物的发育研究表明，细胞命运的决定仅由少数几个高度保守的信号转导级联所控制。最近的数据表明，其中至少有两个，即Wnt和Notch级联，已被脊椎动物免疫系统利用来控制早期淋巴细胞生成。
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