核因子-κB难题中缺失的部分。
Missing pieces in the NF-kappaB puzzle.
作者信息
Ghosh Sankar, Karin Michael
机构信息
Section of Immunobiology, Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA.
出版信息
Cell. 2002 Apr;109 Suppl:S81-96. doi: 10.1016/s0092-8674(02)00703-1.
The regulation of the transcription factor NF-kappaB activity occurs at several levels including controlled cytoplasmic-nuclear shuttling and modulation of its transcriptional activity. A critical component in NF-kappaB regulation is the IkappaB kinase (IKK) complex. This review is focused on recent progress as well as unanswered questions regarding the regulation and function of NF-kappaB and IKK.
转录因子NF-κB活性的调控发生在多个层面，包括受控的胞质-核穿梭及其转录活性的调节。NF-κB调控中的一个关键组分是IκB激酶（IKK）复合体。本综述聚焦于关于NF-κB和IKK调控与功能的最新进展以及尚未解答的问题。
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