Trape Jean François, Pison Gilles, Spiegel André, Enel Catherine, Rogier Christophe
Institut de Recherche pour le Développement (IRD, formerly ORSTOM), BP 1386, Dakar, Senegal.
Trends Parasitol. 2002 May;18(5):224-30. doi: 10.1016/s1471-4922(02)02249-3.
The spread of antimalarial drug resistance has major consequences for malaria control in tropical Africa. Here, the impact of chloroquine resistance on the burden of malaria is analyzed and its implications for the Roll Back Malaria initiative are examined. Malaria mortality has increased at least twofold during the past two decades. Combination therapy should be available for home treatment of young children. The potential toxicity of most antimalarials will require special surveillance programs. The main contribution to malaria control using methods to reduce the entomological inoculation rate is expected in areas with low or unstable transmission. Classic vector-control methods could potentially eliminate malaria in most urban areas and such programs deserve high priority.
抗疟药物耐药性的传播对热带非洲的疟疾控制产生了重大影响。本文分析了氯喹耐药性对疟疾负担的影响，并探讨了其对“击退疟疾”倡议的意义。在过去二十年中，疟疾死亡率至少增加了两倍。应提供联合疗法用于幼儿的家庭治疗。大多数抗疟药物的潜在毒性将需要特别的监测计划。利用降低昆虫接种率的方法对疟疾控制的主要贡献预计将出现在传播率低或不稳定的地区。经典的病媒控制方法有可能在大多数城市地区消除疟疾，此类计划应列为高度优先事项。
