Trape J F, Pison G, Preziosi M P, Enel C, Desgrées du Loû A, Delaunay V, Samb B, Lagarde E, Molez J F, Simondon F
Laboratoire de paludologie, Orstom, Dakar, Senegal.
C R Acad Sci III. 1998 Aug;321(8):689-97. doi: 10.1016/s0764-4469(98)80009-7.
Over 12 years, from 1984 to 1995, we conducted a prospective study of overall and malaria specific mortality among three rural populations in the Sahel, savanna and forest areas of Senegal. The emergence of chloroquine resistance has been associated with a dramatic increase in malaria mortality in each of the studied populations. After the emergence of chloroquine resistance, the risk of malaria death among children 0-9 years old in the three populations was multiplied by 2.1, 2.5 and 5.5, respectively. This is the first study to document malaria mortality at the community level in Africa before and after the emergence of chloroquine resistance. Findings suggest that the spread of chloroquine resistance has had a dramatic impact on the level of malaria mortality in most epidemiological contexts in tropical Africa.
从1984年到1995年的12年间，我们对塞内加尔萨赫勒、稀树草原和森林地区的三个农村人口的总体死亡率和疟疾特异性死亡率进行了前瞻性研究。氯喹耐药性的出现与每个研究人群中疟疾死亡率的急剧上升有关。氯喹耐药性出现后，这三个人口中0至9岁儿童的疟疾死亡风险分别增加到原来的2.1倍、2.5倍和5.5倍。这是第一项记录非洲氯喹耐药性出现前后社区层面疟疾死亡率的研究。研究结果表明，氯喹耐药性的传播对热带非洲大多数流行病学环境中的疟疾死亡率水平产生了巨大影响。
