CD10有助于显示异位部位的子宫内膜间质，并有助于确诊子宫内膜异位症。
CD10 is useful in demonstrating endometrial stroma at ectopic sites and in confirming a diagnosis of endometriosis.
作者信息
Sumathi V P, McCluggage W G
机构信息
Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast BT12 6BL, Northern Ireland.
出版信息
J Clin Pathol. 2002 May;55(5):391-2. doi: 10.1136/jcp.55.5.391.
Abstract
AIMS
Recent studies have shown that CD10 is a useful immunohistochemical marker of normal endometrial stroma and of endometrial stromal neoplasms. The aim of this study was to investigate whether CD10 immunoreactivity is present in ectopic endometrial stroma and whether staining is of value in confirming a diagnosis of endometriosis.
METHODS/RESULTS: Twenty five cases of endometriosis were stained with a commercially available antibody against CD10. Endometrial stromal cells were positive in 22 of 25 cases. There was little or no staining of other tissues.
CONCLUSIONS
CD10 immunoreactivity is largely maintained in endometrial stromal cells located outside the uterus. Immunohistochemical staining with CD10 may be of value in confirming a diagnosis of endometriosis when there is morphological doubt.
摘要
目的
近期研究表明，CD10是正常子宫内膜间质及子宫内膜间质肿瘤有用的免疫组织化学标志物。本研究的目的是调查异位子宫内膜间质中是否存在CD10免疫反应性，以及染色在确诊子宫内膜异位症方面是否有价值。
方法/结果：用市售抗CD10抗体对25例子宫内膜异位症病例进行染色。25例中有22例子宫内膜间质细胞呈阳性。其他组织几乎没有或没有染色。
结论
位于子宫外的子宫内膜间质细胞中CD10免疫反应性大多得以保留。当存在形态学疑问时，CD10免疫组织化学染色在确诊子宫内膜异位症方面可能有价值。
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