Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, 01536, USA.
Department Comparative Pathobiology, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, 01536, USA.
Sci Rep. 2024 Sep 20;14(1):21947. doi: 10.1038/s41598-024-73012-8.
The mpox outbreak of 2022-2023 represented a new global health challenge and recognition of mpox as a sexually transmitted disease. The majority of cases were reported in men who have sex with men (MSM), but women are also susceptible, especially during pregnancy. We evaluated the reproductive tracts of a subset of macaques from a large rechallenge study of mpox infection with virus from the 2022 outbreak and identified intraabdominal mpox replication associated with endometriosis. Mpox virus (MPXV) was found not only in skin, but in the cervix, the uterus, and periovarian endometriotic lesions of the affected macaque. Mpox replication preferentially targeted vimentin-positive poorly differentiated endometriotic stromal tissue and infiltrating macrophages in the reproductive tract. Mpox tropism for stromal cells and macrophages has broad implications for mpox pathogenesis and associated clinical syndromes. In addition, women with endometriosis may be at heightened risk for adverse outcomes associated with mpox infection. The rhesus macaque provides rare insight into this disease and the potential complications of mpox infection in the context of genitourinary tract disease.
2022-2023 年的猴痘疫情代表了新的全球健康挑战，也使人们认识到猴痘是一种性传播疾病。大多数病例报告发生在与男性发生性关系的男性（MSM）中，但女性也易感染，尤其是在怀孕期间。我们评估了来自大型猴痘感染再挑战研究中一部分猕猴的生殖道，这些猕猴感染了来自 2022 年疫情的病毒，并发现与子宫内膜异位症相关的腹内猴痘复制。猴痘病毒（MPXV）不仅存在于皮肤中，还存在于受影响猕猴的宫颈、子宫和卵巢周围子宫内膜异位症病变中。猴痘复制优先靶向 vimentin 阳性的低分化子宫内膜异位症基质组织和生殖道中的浸润巨噬细胞。猴痘对基质细胞和巨噬细胞的趋向性对猴痘发病机制和相关临床综合征具有广泛影响。此外，患有子宫内膜异位症的女性可能面临与猴痘感染相关的不良后果的风险增加。恒河猴为了解这种疾病以及生殖道疾病背景下猴痘感染的潜在并发症提供了难得的见解。
