Paulson Olaf B, Born Alfred Peter, Bundesen Claus, Gade Anders, Gerlach Christian, Hansen Lars Kai, Holm Søren, Jensen Mikael, Kyllingsbaek Søren, Larsen Axel, Law Ian, Rostrup Egill, Svarer Claus
Ugeskr Laeger. 2002 Apr 22;164(17):2267-75.
Numerous brain functions, such as awareness of surroundings, control of movements, thoughts, and memory have always been a kind of mystery, which has provoked human curiosity and thus inspired research in many areas. The present paper gives an overview on imaging research of the human brain's functions. The historical progress is briefly reviewed with the emphasis on major Danish contributions. The major methods of mapping brain functions and their biological basis are mentioned. These methods are positron emission tomography (PET) and functional magnetic resonance imaging (fMRI). They are highly technological and generate enormous amounts of data. Thus, data analysis will per se be a research area in brain imaging. Finally, several examples of the authors' results on functional activation are dealt with. These examples aim to illustrate the research area and its contribution to our increased knowledge of the working brain.
许多大脑功能,如对周围环境的感知、运动控制、思维和记忆,一直是一种谜,这激发了人类的好奇心,从而推动了许多领域的研究。本文概述了人类大脑功能的成像研究。简要回顾了历史进展,重点介绍了丹麦的主要贡献。提及了绘制大脑功能的主要方法及其生物学基础。这些方法是正电子发射断层扫描(PET)和功能磁共振成像(fMRI)。它们技术含量很高,会产生大量数据。因此,数据分析本身将成为脑成像的一个研究领域。最后,讨论了作者关于功能激活的几个结果实例。这些例子旨在说明该研究领域及其对我们增进对工作大脑的了解所做的贡献。