Pastore G, Mosso M L, Magnani C, Luzzatto L, Bianchi M, Terracini B
Childhood Cancer Registry of Piedmont, Cancer Epidemiology Unit of the Centre for Cancer Epidemiology and Prevention, CPO Piedmont, San Giovanni Hospital, Turin, Italy.
Tumori. 2001 Nov-Dec;87(6):372-8. doi: 10.1177/030089160108700603.
The study describes the health status and the attainment of life goals in the adult survivors of childhood cancer recorded at the Childhood Cancer Registry of Piedmont.
A postal questionnaire was sent to the general practitioner of the 690 cases born before 1976 and alive in 1991 after at least 5 years from diagnosis. The answer was received for 485 (72.9%) included in the analyses. Items in the questionnaire were: sequelae related to cancer and its treatment, health-related quality of life (according to Bloom's criteria), educational level attained, and employment status.
Vital and marital status were obtained for all 690 cases at the offices of the town of residence. No medical condition was reported for 309 cases (63.7%). The overall proportion with a high school or university education was compared to corresponding figures for Piedmont in 1991, adjusted by age, and was as high as in the general population. Similar results are observed for occupation. Patients of both genders were married less than expected. Patients with leukemia (112 cases), non-Hodgkin's lymphoma (34) or Hodgkin's lymphoma (52) were reported to have the highest quality of life. In contrast, patients with tumors of the central nervous system (151) had the highest frequency of sequelae and the lowest score for health-related quality of life. They-also presented the lowest educational achievement, the lowest proportion of employment and, among males, the lowest frequency of marriage.
Our study shows a good social adjustment of adult survivors from childhood cancer, with the exception of central nervous system tumors. From the methodologic point of view, the present study shows the feasibility of surveillance surveys on health-related quality of life with the contribution of general practitioners.
本研究描述了皮埃蒙特儿童癌症登记处记录的儿童癌症成年幸存者的健康状况和生活目标达成情况。
向1976年以前出生且在1991年尚存活、诊断后至少5年的690例患者的全科医生发送了邮政调查问卷。收到了485例（72.9%）的回复并纳入分析。调查问卷的项目包括：与癌症及其治疗相关的后遗症、健康相关生活质量（根据布鲁姆标准）、所达到的教育水平和就业状况。
在居住城镇的办事处获取了所有690例患者的生命和婚姻状况。309例（63.7%）未报告任何医疗状况。将高中或大学教育程度的总体比例与1991年皮埃蒙特按年龄调整后的相应数据进行比较，结果与普通人群一样高。职业方面也观察到类似结果。两性患者的结婚率均低于预期。据报告，白血病患者（112例）、非霍奇金淋巴瘤患者（34例）或霍奇金淋巴瘤患者（52例）的生活质量最高。相比之下，中枢神经系统肿瘤患者（151例）的后遗症发生率最高，健康相关生活质量得分最低。他们的教育成就也最低，就业比例最低，男性的结婚率也最低。
我们的研究表明，除中枢神经系统肿瘤外，儿童癌症成年幸存者的社会适应情况良好。从方法学角度来看，本研究表明在全科医生的协助下对健康相关生活质量进行监测调查是可行的。
