Moghaddampour Issa Mousazadeh, Shirini Farhad, Langarudi Mohaddeseh Safarpoor Nikoo
Department of Chemistry, College of Science, University of Guilan, University Campus 2, Rasht, Iran.
Department of Chemistry, College of Science, University of Guilan, Rasht, 41335-19141, Iran.
J Mol Struct. 2021 Feb 15;1226:129336. doi: 10.1016/j.molstruc.2020.129336. Epub 2020 Sep 26.
In this project, a recently synthesized DABCO-based catalyst is entrapped in agar to reduce its moisture sensitivity leading to enhancement of its stability and catalytic activity. After preparation and identification this new reagent is used as an efficient and environmentally safe catalyst for the preparation of 1, 2, 4-triazoloquinazolinone and some pyrimidine derivatives. This method is accompanied with some superiorities such as, simple operation, mild and green conditions, use of low cost and non-hazardous natural material, short reaction times, easy preparation methods and simple work-up procedures. The prepared catalyst can be re-used for several times in all of the studied reactions without any appreciable loss in its activity.
在本项目中，一种最近合成的基于1,4-二氮杂二环[2.2.2]辛烷的催化剂被包埋在琼脂中，以降低其对水分的敏感性，从而提高其稳定性和催化活性。制备并鉴定后，这种新型试剂被用作制备1,2,4-三唑并喹唑啉酮和一些嘧啶衍生物的高效且环境安全的催化剂。该方法具有一些优点，如操作简单、条件温和且绿色、使用低成本且无害的天然材料、反应时间短、制备方法简便以及后处理程序简单。所制备的催化剂在所有研究的反应中均可重复使用多次，其活性没有明显损失。
