• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

骨髓嵌合体揭示了非H-2造血细胞对泰勒氏病毒持续感染易感性的控制。

Bone marrow chimeras reveal non-H-2 hematopoietic control of susceptibility to Theiler's virus persistent infection.

作者信息

Aubagnac Stéphanie, Brahic Michel, Bureau Jean-François

机构信息

Unité des Virus Lents, CNRS URA 1930, Institut Pasteur, 75724 Paris Cedex 15, France.

出版信息

J Virol. 2002 Jun;76(11):5807-12. doi: 10.1128/jvi.76.11.5807-5812.2002.

DOI:10.1128/jvi.76.11.5807-5812.2002
PMID:11992010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC137043/
Abstract

The DA strain of Theiler's murine encephalomyelitis virus persists in the white matter of the spinal cords of susceptible mice. Previous results showed that the difference in susceptibility to viral persistence between the susceptible SJL/J strain and the resistant B10.S strain was due to multiple non-H-2 loci. The respective roles of hematopoietic and nonhematopoietic cells in this difference have been evaluated with bone marrow chimeras. The results show that non-H-2 loci with a major effect on susceptibility are expressed in hematopoietic cells. However, the study of the SJL.B10-D10Mit180-D10Mit74 congenic line suggests that other loci expressed in nonhematopoietic cells also play a role.

摘要

泰勒氏小鼠脑脊髓炎病毒的DA株在易感小鼠脊髓的白质中持续存在。先前的结果表明，易感的SJL/J株和抗性的B10.S株对病毒持续感染的易感性差异是由多个非H-2基因座引起的。已经用骨髓嵌合体评估了造血细胞和非造血细胞在这种差异中的各自作用。结果表明，对易感性有主要影响的非H-2基因座在造血细胞中表达。然而，对SJL.B10-D10Mit180-D10Mit74同源系的研究表明，在非造血细胞中表达的其他基因座也起作用。

相似文献

1
Bone marrow chimeras reveal non-H-2 hematopoietic control of susceptibility to Theiler's virus persistent infection.骨髓嵌合体揭示了非H-2造血细胞对泰勒氏病毒持续感染易感性的控制。
J Virol. 2002 Jun;76(11):5807-12. doi: 10.1128/jvi.76.11.5807-5812.2002.
2
Theiler's virus persistence and demyelination in major histocompatibility complex class II-deficient mice.泰勒氏病毒在主要组织相容性复合体II类缺陷小鼠中的持续感染与脱髓鞘病变
J Virol. 1996 Mar;70(3):1729-37. doi: 10.1128/JVI.70.3.1729-1737.1996.
3
Roles of the H-2D(b) and H-K(b) genes in resistance to persistent Theiler's murine encephalomyelitis virus infection of the central nervous system.H-2D(b)和H-K(b)基因在抵抗中枢神经系统持续性泰勒氏鼠脑脊髓炎病毒感染中的作用。
J Gen Virol. 2001 May;82(Pt 5):1043-1047. doi: 10.1099/0022-1317-82-5-1043.
4
The infection of mouse by Theiler's virus: from genetics to immunology.泰勒氏病毒对小鼠的感染：从遗传学到免疫学
Immunol Rev. 1997 Oct;159:163-76. doi: 10.1111/j.1600-065x.1997.tb01014.x.
5
Infection of class II-deficient mice by the DA strain of Theiler's virus.用泰勒氏病毒DA株感染II类缺陷小鼠。
J Virol. 1996 Jul;70(7):4811-5. doi: 10.1128/JVI.70.7.4811-4815.1996.
6
FVB mice transgenic for the H-2Db gene become resistant to persistent infection by Theiler's virus.携带H-2Db基因的转基因FVB小鼠对泰勒氏病毒的持续感染产生抗性。
J Virol. 1994 Jun;68(6):4049-52. doi: 10.1128/JVI.68.6.4049-4052.1994.
7
A Theiler's virus alternatively initiated protein inhibits the generation of H-2K-restricted virus-specific cytotoxicity.一种泰勒氏病毒交替起始蛋白可抑制H-2K限制的病毒特异性细胞毒性的产生。
J Immunol. 1999 Jan 1;162(1):17-24.
8
The majority of infiltrating CD8+ T cells in the central nervous system of susceptible SJL/J mice infected with Theiler's virus are virus specific and fully functional.感染泰勒病毒的易感SJL/J小鼠中枢神经系统中，大多数浸润的CD8 + T细胞具有病毒特异性且功能完备。
J Virol. 2002 Jul;76(13):6577-85. doi: 10.1128/jvi.76.13.6577-6585.2002.
9
Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus-induced demyelinating disease. VI. Potentiation of demyelination with and characterization of an immunopathologic CD4+ T cell line specific for an immunodominant VP2 epitope.Ⅱ类分子限制性T细胞应答在泰勒鼠脑脊髓炎病毒诱导的脱髓鞘疾病中的作用。VI. 针对免疫显性VP2表位的免疫病理CD4⁺ T细胞系对脱髓鞘的增强作用及其特性
J Immunol. 1994 Jan 15;152(2):919-29.
10
H-2 Dd transgene suppresses Theiler's virus-induced demyelination in susceptible strains of mice.H-2 Dd转基因可抑制易感品系小鼠中泰勒氏病毒诱导的脱髓鞘病变。
J Neurovirol. 1995 Mar;1(1):111-7. doi: 10.3109/13550289509111015.

引用本文的文献

1
Long Noncoding RNAs in Host-Pathogen Interactions.长非编码 RNA 在宿主-病原体相互作用中的作用。
Trends Immunol. 2019 Jun;40(6):492-510. doi: 10.1016/j.it.2019.04.001. Epub 2019 Apr 30.
2
A Refined Bead-Free Method to Identify Astrocytic Exosomes in Primary Glial Cultures and Blood Plasma.一种用于鉴定原代胶质细胞培养物和血浆中星形胶质细胞外泌体的改良无珠方法。
Front Neurosci. 2017 Jun 15;11:335. doi: 10.3389/fnins.2017.00335. eCollection 2017.
3
The level of viral infection of antigen-presenting cells correlates with the level of development of Theiler's murine encephalomyelitis virus-induced demyelinating disease.抗原呈递细胞的病毒感染水平与泰勒氏鼠脑脊髓炎病毒诱导的脱髓鞘疾病的发展程度相关。
J Virol. 2015 Feb;89(3):1867-78. doi: 10.1128/JVI.02471-14. Epub 2014 Nov 26.
4
Astrocyte regulation of CNS inflammation and remyelination.星形胶质细胞对中枢神经系统炎症和髓鞘修复的调节作用。
Brain Sci. 2013 Jul 22;3(3):1109-27. doi: 10.3390/brainsci3031109.
5
The NeST long ncRNA controls microbial susceptibility and epigenetic activation of the interferon-γ locus.NeST 长 ncRNA 控制微生物易感性和干扰素-γ基因座的表观遗传激活。
Cell. 2013 Feb 14;152(4):743-54. doi: 10.1016/j.cell.2013.01.015.
6
IRF3 polymorphisms induce different innate anti-Theiler's virus immune responses in RAW264.7 macrophages.IRF3 多态性诱导 RAW264.7 巨噬细胞中不同的固有抗 Theiler's 病毒免疫反应。
Virology. 2011 Sep 15;418(1):40-8. doi: 10.1016/j.virol.2011.06.028. Epub 2011 Aug 2.
7
Pro-inflammatory functions of astrocytes correlate with viral clearance and strain-dependent protection from TMEV-induced demyelinating disease.星形胶质细胞的促炎功能与病毒清除以及对TMEV诱导的脱髓鞘疾病的毒株依赖性保护相关。
Virology. 2008 May 25;375(1):24-36. doi: 10.1016/j.virol.2008.01.024. Epub 2008 Mar 4.
8
Interleukin 22 is a candidate gene for Tmevp3, a locus controlling Theiler's virus-induced neurological diseases.白细胞介素22是Tmevp3的一个候选基因，Tmevp3是一个控制泰勒氏病毒引起的神经疾病的基因座。
Genetics. 2007 Jul;176(3):1835-44. doi: 10.1534/genetics.107.073536. Epub 2007 May 4.
9
Gamma delta T cells provide an early source of interferon gamma in tumor immunity.γδ T细胞在肿瘤免疫中提供了干扰素γ的早期来源。
J Exp Med. 2003 Aug 4;198(3):433-42. doi: 10.1084/jem.20030584.
10
Tmevpg1, a candidate gene for the control of Theiler's virus persistence, could be implicated in the regulation of gamma interferon.Tmevpg1是控制泰勒氏病毒持续性的一个候选基因，可能参与γ干扰素的调节。
J Virol. 2003 May;77(10):5632-8. doi: 10.1128/jvi.77.10.5632-5638.2003.

本文引用的文献

1
Viral load increases in SJL/J mice persistently infected by Theiler's virus after inactivation of the beta(2)m gene.在β2m基因失活后，持续感染泰勒氏病毒的SJL/J小鼠体内病毒载量增加。
J Virol. 2001 Aug;75(16):7723-6. doi: 10.1128/JVI.75.16.7723-7726.2001.
2
High numbers of viral RNA copies in the central nervous system of mice during persistent infection with Theiler's virus.在感染泰勒氏病毒的小鼠持续感染期间，其中枢神经系统中存在大量病毒RNA拷贝。
J Virol. 2001 Aug;75(16):7420-8. doi: 10.1128/JVI.75.16.7420-7428.2001.
3
Roles of the H-2D(b) and H-K(b) genes in resistance to persistent Theiler's murine encephalomyelitis virus infection of the central nervous system.H-2D(b)和H-K(b)基因在抵抗中枢神经系统持续性泰勒氏鼠脑脊髓炎病毒感染中的作用。
J Gen Virol. 2001 May;82(Pt 5):1043-1047. doi: 10.1099/0022-1317-82-5-1043.
4
H-2D(b-/-) mice are susceptible to persistent infection by Theiler's virus.H-2D(b-/-)小鼠易受泰勒氏病毒的持续感染。
J Virol. 2000 Jun;74(12):5470-6. doi: 10.1128/jvi.74.12.5470-5476.2000.
5
Viral load and a locus on chromosome 11 affect the late clinical disease caused by Theiler's virus.病毒载量和11号染色体上的一个基因座会影响由泰勒氏病毒引起的晚期临床疾病。
J Virol. 1999 Oct;73(10):7965-71. doi: 10.1128/JVI.73.10.7965-7971.1999.
6
The Th1/Th2 balance does not account for the difference of susceptibility of mouse strains to Theiler's virus persistent infection.Th1/Th2平衡并不能解释小鼠品系对泰勒氏病毒持续感染易感性的差异。
J Immunol. 1999 Jun 15;162(12):7330-4.
7
Two loci, Tmevp2 and Tmevp3, located on the telomeric region of chromosome 10, control the persistence of Theiler's virus in the central nervous system of mice.位于10号染色体端粒区域的两个基因座Tmevp2和Tmevp3控制着泰勒氏病毒在小鼠中枢神经系统中的持续性。
Genetics. 1999 May;152(1):385-92. doi: 10.1093/genetics/152.1.385.
8
Genetics of susceptibility to Theiler's virus infection.泰勒氏病毒感染易感性的遗传学
Bioessays. 1998 Aug;20(8):627-33. doi: 10.1002/(SICI)1521-1878(199808)20:8<627::AID-BIES5>3.0.CO;2-F.
9
Protein 2A is not required for Theiler's virus replication.Theiler病毒复制不需要蛋白质2A。
J Virol. 1997 Dec;71(12):9549-56. doi: 10.1128/JVI.71.12.9549-9556.1997.
10
The immune system preferentially clears Theiler's virus from the gray matter of the central nervous system.免疫系统优先从中枢神经系统的灰质中清除泰勒氏病毒。
J Virol. 1997 Nov;71(11):8592-601. doi: 10.1128/JVI.71.11.8592-8601.1997.