Department of Immunology, School of Medicine, UConn Health, 263 Farmington Avenue, Farmington, CT 06030, USA.
Department of Immunology, School of Medicine, UConn Health, 263 Farmington Avenue, Farmington, CT 06030, USA.
Trends Immunol. 2019 Jun;40(6):492-510. doi: 10.1016/j.it.2019.04.001. Epub 2019 Apr 30.
Long noncoding RNAs (lncRNAs) are key molecules that regulate gene expression in a variety of organisms. LncRNAs can drive different transcriptional and post-transcriptional events that impact cellular functions. Recent studies have identified many lncRNAs associated with immune cell development and activation; however, an understanding of their functional role in host immunity to infection is just emerging. Here, we provide a detailed and updated review of the functional roles of lncRNAs in regulating mammalian immune responses during host-pathogen interactions, because these functions may be either beneficial or detrimental to the host. With increased mechanistic insight into the roles of lncRNAs, it may be possible to design and/or improve lncRNA-based therapies to treat a variety of infectious and inflammatory diseases.
长链非编码 RNA（lncRNA）是调节多种生物中基因表达的关键分子。lncRNA 可以驱动影响细胞功能的不同转录和转录后事件。最近的研究已经确定了许多与免疫细胞发育和激活相关的 lncRNA；然而，人们对它们在宿主抗感染免疫中的功能作用的理解才刚刚开始。在这里，我们提供了一个详细和更新的综述，介绍 lncRNA 在调节哺乳动物免疫反应中的功能作用，因为这些功能可能对宿主有益或有害。随着对 lncRNA 作用机制的深入了解，可能有可能设计和/或改进基于 lncRNA 的疗法来治疗各种感染和炎症性疾病。
