用泰勒氏病毒DA株感染II类缺陷小鼠。
Infection of class II-deficient mice by the DA strain of Theiler's virus.
作者信息
Fiette L, Brahic M, Pena-Rossi C
机构信息
Unité des Virus Lents, URA 1157 Centre National de la Recherche Scientifique, Institut Pasteur, France.
出版信息
J Virol. 1996 Jul;70(7):4811-5. doi: 10.1128/JVI.70.7.4811-4815.1996.
Abstract
The DA strain of Theiler's virus causes, in susceptible strains of mice, a persistent infection of the white matter of the spinal cord accompanied by chronic inflammation and primary demyelination. In resistant strains, including all H-2b strains, mice clear the infection after 1 to 2 weeks. We inoculated RHAbetao/o mice, an H-2b strain which does not express class II molecules. We found that they are susceptible to persistent infection and that they develop foci of chronic inflammation with demyelination. However, these foci are smaller and contain fewer demyelinated axons than those observed in susceptible SJL/J or beta2m-/- mice.
摘要
泰勒氏病毒的DA毒株在易感小鼠品系中会导致脊髓白质的持续性感染，并伴有慢性炎症和原发性脱髓鞘。在包括所有H-2b品系在内的抗性品系中，小鼠在1至2周后清除感染。我们接种了RHAbetao/o小鼠，这是一种不表达II类分子的H-2b品系。我们发现它们易受持续性感染，并且会出现伴有脱髓鞘的慢性炎症病灶。然而，这些病灶比在易感的SJL/J或β2m-/-小鼠中观察到的病灶更小，且脱髓鞘轴突更少。
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