Wiertz E J, Tortorella D, Bogyo M, Yu J, Mothes W, Jones T R, Rapoport T A, Ploegh H L
Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA.
Nature. 1996 Dec 5;384(6608):432-8. doi: 10.1038/384432a0.
The human cytomegalovirus genome encodes proteins that trigger destruction of newly synthesized major histocompatibility complex (MHC) class I molecules. The human cytomegalovirus gene US2 specifies a product capable of dislocating MHC class I molecules from the endoplasmic reticulum to the cytosol and delivering them to the proteasome. This process involves the Sec61 complex, in what appears to be a reversal of the reaction by which it translocates nascent chains into the endoplasmic reticulum.
人类巨细胞病毒基因组编码的蛋白质可引发新合成的主要组织相容性复合体（MHC）I类分子的破坏。人类巨细胞病毒基因US2编码的产物能够将MHC I类分子从内质网转运至细胞质溶胶，并将它们递送至蛋白酶体。这一过程涉及Sec61复合体，这似乎是其将新生肽链转运至内质网的反应的逆转。
