Mano Takamitsu, Ueyama Yoshiya, Ishikawa Kunio, Matsumura Tomohiro, Suzuki Kazuomi
Departmnent of Oral and Maxillofacial Surgery II, Okayama University Dental School, Japan.
Biomaterials. 2002 May;23(9):1931-6. doi: 10.1016/s0142-9612(01)00319-2.
We previously reported a blast coating method (BC method) as a new coating method of titanium (Ti) with apatite (AP) at room temperature. The BC method gives much stronger AP coating on the Ti surface compared with those obtained by other room temperature coating methods. However, no in vivo study has been made, so far, to evaluate the stability or the tissue response to the implant. As an initial step to evaluate the feasibility of the BC method, we evaluated the tissue response and stability of AP coated Ti implant prepared with the BC method (AP-BC implant) using rats as experimental animals. The AP coating adhered tightly to the Ti surface even after the implant procedure and throughout the experimental period up to six weeks post operation. AP-BC implant caused no inflammatory response, showed strong bone response and much better osteoconductivity compared with the pure Ti implant. The new bone formed on the surface of AP-BC implants was thinner compared with that formed on the surface of Ti implant. Therefore, the AP-BC implant has a good potential as an osteoconductive implant material.
我们之前报道了一种喷砂涂层法（BC法），作为一种在室温下用磷灰石（AP）对钛（Ti）进行涂层的新方法。与其他室温涂层法相比，BC法在Ti表面形成的AP涂层要强得多。然而，迄今为止尚未进行体内研究来评估该植入物的稳定性或组织反应。作为评估BC法可行性的第一步，我们以大鼠为实验动物，评估了用BC法制备的AP涂层Ti植入物（AP-BC植入物）的组织反应和稳定性。即使在植入手术后以及直至术后六周的整个实验期间，AP涂层仍紧密附着在Ti表面。与纯Ti植入物相比，AP-BC植入物未引起炎症反应，表现出强烈的骨反应和更好的骨传导性。AP-BC植入物表面形成的新骨比Ti植入物表面形成的新骨更薄。因此，AP-BC植入物作为一种骨传导植入材料具有良好的潜力。
