Matsuo O, Kawaguchi T, Kosugi T, Mihara H, Kimura T
Thromb Haemost. 1979 Aug 31;42(2):596-602.
UK excretion rate in the diuretic state was investigated in human and animal studies. Loading of water, beer or diuretics in man decreased the UK excretion rate as urine flow increased. A linear relation between UK excretion rate and urine specific gravity was observed. Simultaneous loading of water and exercise suppressed the decrease in UK excretion rate and the increase in urine flow. In animal studies, a null value for UK excretion rate was observed as a result of giving physiological saline and/or furosemide, and a remarkable increase in urine flow was induced. These results clearly suggest the existence of a relation between renal function and UK excretion rate.
在人体和动物研究中对处于利尿状态下的尿激酶排泄率进行了调查。在人体中，摄入水、啤酒或利尿剂会随着尿量增加而降低尿激酶排泄率。观察到尿激酶排泄率与尿比重之间呈线性关系。同时摄入水并进行运动可抑制尿激酶排泄率的降低和尿量的增加。在动物研究中，给予生理盐水和/或速尿后观察到尿激酶排泄率为零值，并诱导尿量显著增加。这些结果清楚地表明肾功能与尿激酶排泄率之间存在关联。
