McGavin C R, Marshall A J, Lewis C T
Department of Respiratory Medicine, Derriford Hospital, Plymouth PL6 8DH, UK.
Heart. 2002 May;87(5):E5. doi: 10.1136/heart.87.5.e5.
A case is presented of the Churg-Strauss syndrome with hypereosinophilia and severe cardiac involvement, namely biventricular endomyocardial fibrosis and gross encroachment of the right ventricular cavity. The clinical picture was similar to Loeffler's syndrome and the idiopathic hypereosinophilic syndrome. Combined aggressive surgical and medical management led to full recovery and survival at 10 years. The good long term outcome is attributed to strict control of peripheral eosinophil count by oral corticosteroids. This case illustrates the damaging effects of hypereosinophilia on the heart.
本文报告一例伴有嗜酸性粒细胞增多和严重心脏受累的Churg-Strauss综合征，即双心室心内膜纤维化和右心室腔明显受压。临床表现与吕弗勒综合征和特发性嗜酸性粒细胞增多综合征相似。积极的手术和药物联合治疗使患者完全康复并存活了10年。长期良好预后归因于口服糖皮质激素对外周血嗜酸性粒细胞计数的严格控制。该病例说明了嗜酸性粒细胞增多对心脏的损害作用。
