Kitano Katsunori, Câteau Hideyuki, Fukai Tomoki
Department of Information-Communication Engineering, Tamagawa University, 6-1-1 Tamagawagakuen, Machida, Tokyo 194-8610, Japan.
Neuroreport. 2002 May 7;13(6):795-8. doi: 10.1097/00001756-200205070-00012.
We studied the self-organization of memory-related activity through spike-timing-dependent plasticity (STDP). Relatively short time windows (approximately 10 ms) for the plasticity rule give rise to asynchronous persistent activity of low rates (20-30 Hz), which is typically observed in delay periods of working memory task. We demonstrate some network level effects on the activity regulation that cannot be addressed in single-neuron studies. For longer time windows (approximately 20 ms), the layered cell assemblies that propagate synchronized spikes (synfire chain) are self-organized. Synchronous spike propagation was suggested to underlie the precisely timed spikes in the monkey prefrontal cortex. The present results suggest that the two networks for sustained activity are different realizations of the same principle for synaptic wiring.
我们通过依赖于尖峰时间的可塑性（STDP）研究了与记忆相关活动的自组织。可塑性规则相对较短的时间窗口（约10毫秒）会引发低频率（20 - 30赫兹）的异步持续活动，这在工作记忆任务的延迟期通常可以观察到。我们展示了一些在单神经元研究中无法解决的对活动调节的网络层面效应。对于更长的时间窗口（约20毫秒），传播同步尖峰的分层细胞组件（同步发放链）会自组织形成。有人提出同步尖峰传播是猴子前额叶皮层中精确计时尖峰的基础。目前的结果表明，用于持续活动的这两种网络是同一突触连接原则的不同实现方式。
