McGehee Daniel S
Dept of Anesthesia and Critical Care, University of Chicago, 5841 S. Maryland Ave, MC4028, Chicago, IL 60637, USA.
Trends Neurosci. 2002 Apr;25(4):171-2. doi: 10.1016/s0166-2236(00)02127-5.
As we learn more about the functional expression of nicotinic receptors in specific brain regions such as the hippocampus, intriguing interactions are being uncovered at the cellular and circuit levels. Recent work from John Dani's laboratory provides important insights into how nicotinic receptors can modify hippocampal synaptic plasticity in both positive and negative ways, and this could help explain the role of nicotinic receptors in learning and memory.
随着我们对烟碱型受体在特定脑区（如海马体）的功能表达了解得越来越多，在细胞和神经回路水平上正在发现有趣的相互作用。约翰·达尼实验室最近的研究工作为烟碱型受体如何以正负两种方式改变海马体突触可塑性提供了重要见解，这有助于解释烟碱型受体在学习和记忆中的作用。
