von Mering Christian, Krause Roland, Snel Berend, Cornell Michael, Oliver Stephen G, Fields Stanley, Bork Peer
European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany.
Nature. 2002 May 23;417(6887):399-403. doi: 10.1038/nature750. Epub 2002 May 8.
Comprehensive protein protein interaction maps promise to reveal many aspects of the complex regulatory network underlying cellular function. Recently, large-scale approaches have predicted many new protein interactions in yeast. To measure their accuracy and potential as well as to identify biases, strengths and weaknesses, we compare the methods with each other and with a reference set of previously reported protein interactions.
全面的蛋白质-蛋白质相互作用图谱有望揭示细胞功能背后复杂调控网络的诸多方面。最近，大规模方法已经预测出酵母中许多新的蛋白质相互作用。为了衡量这些方法的准确性和潜力，以及识别偏差、优势和劣势，我们将这些方法相互比较，并与一组先前报道的蛋白质相互作用的参考集进行比较。
