Benazzo Marco, Occhini Antonio, Rossi Vanessa, Aresi Giuseppe, Alessiani Mario
Dept, of Otorhinolaryngology, University of Pavia, IRCCS Policlinico S, Matteo, Pavia, Italy.
BMC Cancer. 2002 May 10;2:13. doi: 10.1186/1471-2407-2-13.
Surgical treatment of hypopharyngeal cancers with extension to the retrocricoid region generally requires a circumferential pharyngolaryngectomy followed by a reconstruction of the removed segment of the upper digestive tract. Historically, many techniques have been used in order to achieve a safe and functional reconstruction. Jejunum interposition is generally considered the best reconstructive technique.
This study examines the details of the surgical technique, the complications, the oncological and the functional results in a series of 29 consecutive patients submitted to circumferential pharyngoesophageal resection for advanced hypopharyngeal cancer followed by reconstruction with a free flap of jejunum.
Three of the transplants failed because of venous thrombosis. The overall success rate was 90%. There were no general complications. A good swallowing has been preserved in all our patients. All our patients where a phonatory prosthesis was positioned (20/29) were able to achieve speech following speech therapy and all were satisfied with their own capacity to communicate.
The prognosis of hypopharyngeal tumours (18-40% at 5 years) remains poor, but jejunum autografts are being shown to be an excellent choice for the reconstruction of the cervical hypopharyngo-oesophagus offering the patient fast rehabilitation and a reasonable quality of survival. Our experience confirm that this kind of reconstruction is safe with a good results in improving oncologic controls and restoring a good quality of life.
下咽癌侵犯至环状软骨后区的手术治疗通常需要进行环周性咽喉切除术,随后对上消化道切除段进行重建。从历史上看,为实现安全且功能良好的重建,人们使用了多种技术。空肠移植通常被认为是最佳的重建技术。
本研究探讨了一系列连续29例因晚期下咽癌接受环周性咽食管切除术并随后用游离空肠瓣重建的患者的手术技术细节、并发症、肿瘤学及功能结果。
3例移植因静脉血栓形成失败。总体成功率为90%。无全身并发症。所有患者均保留了良好的吞咽功能。所有植入发音假体的患者(20/29)在言语治疗后均能发声,且对自身交流能力均感满意。
下咽肿瘤的预后(5年生存率为18 - 40%)仍然较差,但自体空肠移植已被证明是重建颈段下咽 - 食管的极佳选择,能使患者快速康复并获得合理的生存质量。我们的经验证实,这种重建方式安全,在改善肿瘤学控制及恢复良好生活质量方面效果良好。