Akioka Hiroshi, Uemura Hirokazu, Masui Takashi, Ota Ichiro, Kimura Takahiro, Adachi Shiori, Ueda Keita, Shugyo Masayuki, Tanaka Akihisa, Kitahara Tadashi
Department of Otolaryngology-Head and Neck Surgery, Kindai University Nara Hospital, Ikoma, Nara 630-0293, Japan.
Department of Otolaryngology-Head and Neck Surgery, Nara Medical University, Kashihara, Nara 634-8522, Japan.
Mol Clin Oncol. 2022 May 25;17(1):116. doi: 10.3892/mco.2022.2549. eCollection 2022 Jul.
Reconstructive surgery using the free jejunum flap for locally advanced head and neck cancer is effective in preserving the swallowing function; however, it does not allow normal oral intake in all patients. A total of 47 patients underwent surgery at Nara Medical University between Jan 2010 and Dec 2019. The patients' ages ranged from 48 to 86 years. Sites were the hypopharynx (33 cases), larynx and cervical esophagus (5 cases each) and oropharynx (4 cases). Swallowing function was assessed using videofluorography, from the start of oral intake to discharge, as well as meal form at discharge. Lateral-retropharyngeal-lymph node dissection (LRPLND), preoperative radiation therapy, extended resection to the nasopharynx and incidence of stenosis in the jejuno-esophageal anastomosis were examined. Significant differences were revealed in the scores of pharyngeal residues of contrast medium and pharyngeal contraction, with and without preoperative radiotherapy. LRPLND did not affect swallowing function; dissection group cases had lower scores for soft palate elevation. Overall, resection extended to the nasopharynx, and the anastomosis method did not affect scores of swallowing function.
使用游离空肠瓣对局部晚期头颈癌进行重建手术在保留吞咽功能方面是有效的;然而,并非所有患者都能实现正常经口进食。2010年1月至2019年12月期间,共有47例患者在奈良医科大学接受了手术。患者年龄在48岁至86岁之间。病变部位包括下咽(33例)、喉和颈段食管(各5例)以及口咽(4例)。从开始经口进食到出院期间,使用电视荧光吞咽造影评估吞咽功能,并评估出院时的进食形式。检查了咽后外侧淋巴结清扫术(LRPLND)、术前放疗、向鼻咽部的扩大切除以及空肠食管吻合口狭窄的发生率。在有无术前放疗的情况下,造影剂的咽部残留和咽部收缩评分显示出显著差异。LRPLND不影响吞咽功能;清扫组病例的软腭抬高评分较低。总体而言,向鼻咽部的扩大切除以及吻合方法不影响吞咽功能评分。