Ryan Maria Emanuel
Department of Oral Biology and Pathology, School of Dental Medicine, State University of New York at Stony Brook, 11794-8702, USA.
J Calif Dent Assoc. 2002 Apr;30(4):285-8, 290-5.
A better understanding of the pathogenesis of periodontitis has resulted in pharmacotherapeutic advancements, addressing both the microbes and the host response, leading to improved management of this chronic progressive disease by the dental practitioner. The adjunctive use of host-modulatory agents can enhance therapeutic responses, slow the progression of the disease, and allow for more-predictable management of patients. This article will review the pathogenesis and risk factors associated with periodontitis and address in detail the concept and clinical utility of host modulation as a therapeutic strategy.
对牙周炎发病机制的更深入了解推动了药物治疗的进展，既针对微生物，也针对宿主反应，使牙科医生能够更好地管理这种慢性进展性疾病。辅助使用宿主调节因子可增强治疗反应，减缓疾病进展，并使患者管理更具可预测性。本文将回顾与牙周炎相关的发病机制和危险因素，并详细阐述宿主调节作为一种治疗策略的概念和临床应用。
