Ryan Maria Emanuel
State University of New York at Stony Brook, School of Dental Medicine, Stony Brook, New York, USA.
Compend Contin Educ Dent. 2002 Nov;23(11A):1071-6, 1079-80, 1082.
A better understanding of the pathogenesis of periodontitis has resulted in pharmacotherapeutic advancements that address both the microbes and the host response, leading to improved management of this chronic progressive disease by the dental practitioner. The adjunctive use of host modulatory therapy can enhance therapeutic responses, slow the progression of the disease, and allow for more predictable management of patients, particularly in those patients at increased risk caused by factors beyond the reach of conventional therapeutic approaches. This article reviews the pathogenesis and risk factors associated with periodontitis and addresses, in detail, the concept and clinical use of host modulation as a therapeutic strategy.
对牙周炎发病机制的更深入理解带来了药物治疗方面的进展，这些进展兼顾了微生物和宿主反应，使牙科医生对这种慢性进展性疾病的管理得到改善。宿主调节疗法的辅助使用可增强治疗反应，减缓疾病进展，并使患者管理更具可预测性，特别是对于那些因传统治疗方法无法触及的因素而风险增加的患者。本文综述了与牙周炎相关的发病机制和危险因素，并详细阐述了宿主调节作为一种治疗策略的概念和临床应用。
