Pullmann H, Steigleder G K
Arch Dermatol Res (1975). 1975 Oct 29;253(3):219-24. doi: 10.1007/BF00561147.
By labelling dermal infiltrate cells with H3-thymidine, two types of skin tumours can be distinguished: one type with many labelled cells in the infiltrate (H3-thymidine labelling index, H3-I), the other with few labelled cells. Type I includes malignant melanoma (H3-I = 2.2%) and hemangioendothelioma (2.8%). Type II includes metastases of malignant melanoma (1%), squamous cell carcinoma (1.1%), basel cell epithelioma (0.5%), nevus cell nevus (0.6%), and nevoid lentigo (0.4). The number of labelled cells in the cellular reaction of Type II tumours does not differ significantly from that in normal human corium (0.75%), though there may be a dense cellular reaction. DNA-synthesizing cells were classified with the aid of characteristical stainings and histochemical methods. A vast majority of them were found to be lymphocytes. Our research underlines the special importance of cellular inflammatory reaction, i.e. cellular immunity, im malignant melanoma and probably in hemangioendothelioma.
通过用³H-胸腺嘧啶核苷标记皮肤浸润细胞，可区分出两种类型的皮肤肿瘤：一种是浸润中有许多标记细胞的类型（³H-胸腺嘧啶核苷标记指数，H3-I），另一种是标记细胞很少的类型。I型包括恶性黑色素瘤（H3-I = 2.2%）和血管内皮瘤（2.8%）。II型包括恶性黑色素瘤转移灶（1%）、鳞状细胞癌（1.1%）、基底细胞上皮瘤（0.5%）、痣细胞痣（0.6%）和痣样雀斑（0.4%）。II型肿瘤细胞反应中的标记细胞数量与正常人真皮中的标记细胞数量（0.75%）相比无显著差异，尽管可能存在密集的细胞反应。借助特征性染色和组织化学方法对DNA合成细胞进行分类。发现其中绝大多数是淋巴细胞。我们的研究强调了细胞炎症反应即细胞免疫在恶性黑色素瘤以及可能在血管内皮瘤中的特殊重要性。
