Chapman V M
Biochem Genet. 1975 Dec;13(11-12):849-56. doi: 10.1007/BF00484415.
An electrophoretic polymorphism of 6-phosphogluconate dehydrogenase (PGD) has been observed in the subspecies Mus musculus musculus from northern Denmark. M. m. musculus is interfertile with inbred strains of mice, and F1 hybrids with C57BL/6J show a three-banded phenotype. This pattern is consistent with a dimeric enzyme structure with codominant expression of alleles. In backcrosses and the F2 generation, PGD segregated as a singly autosomal gene, designated Pgd, closely linked to Gpd-1 on chromosome 4(1.7 +/- 1.1%). Both gene products are dimers, both require NADP, and these enzymes catalyze sequential steps in metabolism.
在丹麦北部的小家鼠（Mus musculus musculus）亚种中观察到了6-磷酸葡萄糖酸脱氢酶（PGD）的电泳多态性。小家鼠与近交系小鼠可相互杂交，与C57BL/6J的F1杂种表现出三条带的表型。这种模式与具有等位基因共显性表达的二聚体酶结构一致。在回交和F2代中，PGD作为一个单常染色体基因分离，命名为Pgd，与4号染色体上的Gpd-1紧密连锁（1.7 +/- 1.1%）。这两种基因产物都是二聚体，都需要NADP，并且这些酶催化代谢中的连续步骤。
