List Benjamin
The Scripps Research Institute, Department of Molecular Biology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
J Am Chem Soc. 2002 May 22;124(20):5656-7. doi: 10.1021/ja0261325.
The first direct catalytic asymmetric alpha-amination of aldehydes is described herein. alpha-Unbranched aldehydes react in this novel proline-catalyzed reaction with dialkyl azodicarboxylates to give alpha-amino aldehydes in excellent yields and enantioselectivities.
本文描述了醛的首例直接催化不对称α-胺化反应。在这一新型脯氨酸催化反应中，α-无支链醛与偶氮二羧酸二烷基酯反应，以优异的产率和对映选择性生成α-氨基醛。
