脯氨酸催化的α,α-二取代醛的不对称胺化反应：构型稳定的对映体富集α-氨基醛的合成
Proline-catalysed asymmetric amination of alpha,alpha-disubstituted aldehydes: synthesis of configurationally stable enantioenriched alpha-aminoaldehydes.
作者信息
Vogt Henning, Vanderheiden Sylvia, Bräse Stefan
机构信息
Kekulé-Institut für Organische Chemie und Biochemie der Rheinischen Friedrich-Wilhelms-Universität Bonn, Gerhard-Domagk-Str. 1, D-53121 Bonn, Germany.
出版信息
Chem Commun (Camb). 2003 Oct 7(19):2448-9. doi: 10.1039/b305465a.
DOI:10.1039/b305465a
PMID:14587725
Abstract
Proline-catalysed amination of alpha,alpha-disubstituted racemic aldehydes with azodicarboxylates proceeds smoothly to give configurationally stable scalemic aldehydes and oxazolidinones in up to 86% ee.
摘要
脯氨酸催化α,α-二取代外消旋醛与偶氮二羧酸酯的胺化反应顺利进行，可得到构型稳定的非对映体过量高达86%的醛和恶唑烷酮。
Zotero 插件