通过二茂镍催化实现β-酮酯的直接、收敛α-酰胺化反应。
Direct, Convergent α-Amidation of β-Keto Esters via Nickelocene Catalysis.
作者信息
Sharp Kimberly R, Siddiqui Sara Y, Nikas Emily G, Stoltz Brian M
机构信息
The Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.
出版信息
Org Lett. 2025 Jun 20;27(24):6380-6384. doi: 10.1021/acs.orglett.5c01621. Epub 2025 Jun 5.
α-Amidation of carbonyl-containing compounds without prefunctionalization of starting materials represents a continuing challenge within the scientific community. Here, nickelocene is used catalytically to effect an amidation of β-keto esters. Broad substrate tolerance on both coupling partners is achieved, enabling the application toward a convergent synthetic strategy. Initial mechanistic investigations suggest complex activation pathways.
在不预先官能化起始原料的情况下对含羰基化合物进行α-酰胺化，仍然是科学界面临的一项挑战。在此，二茂镍被用于催化β-酮酯的酰胺化反应。该反应对两种偶联底物都具有广泛的耐受性，从而能够应用于汇聚式合成策略。初步的机理研究表明存在复杂的活化途径。
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