Rippke Frank, Schreiner Volker, Schwanitz Hans-Joachim
Beiersdorf AG, Hamburg, Germany.
Am J Clin Dermatol. 2002;3(4):261-72. doi: 10.2165/00128071-200203040-00004.
The acidic pH of the horny layer, measurable on the skin surface, has long been regarded as a result of exocrine secretion of the skin glands. The 'acid mantle' was thought to regulate the bacterial skin flora and to be sensitive primarily to skin cleansing procedures. In recent years, an increasing number of investigations have been published on the changes in, and constituents and functions of, the pH of the deeper layers of the stratum corneum, as well as on the influence of physiological and pathological factors. A central role for the acidic milieu as a regulating factor in stratum corneum homeostasis is now emerging. This has relevance to the integrity of the barrier function, from normal maturation of the stratum corneum lipids through to desquamation. Changes in the pH and the organic factors influencing it appear to play a role, not only in the pathogenesis, prevention and treatment of irritant contact dermatitis, but also of atopic dermatitis and ichthyosis and in wound healing. On the basis of these findings, a broader concept, exceeding the superficial 'acid mantle' theory, has been formulated.
角质层的酸性pH值可在皮肤表面测量，长期以来一直被认为是皮肤腺体外分泌的结果。“酸性保护膜”被认为可调节皮肤细菌菌群，且主要对皮肤清洁程序敏感。近年来，关于角质层深层pH值的变化、成分及功能，以及生理和病理因素的影响，已有越来越多的研究发表。酸性环境作为角质层稳态调节因子的核心作用正逐渐显现。这与屏障功能的完整性相关，从角质层脂质的正常成熟到脱屑。pH值及其影响因素的变化似乎不仅在刺激性接触性皮炎、特应性皮炎和鱼鳞病的发病机制、预防和治疗中起作用，而且在伤口愈合中也起作用。基于这些发现，已形成了一个超越表面“酸性保护膜”理论的更广泛概念。
