Serpico Luigia, Dello Iacono Stefania, Cammarano Aniello, De Stefano Luca
Institute of Applied Sciences and Intelligent Systems (ISASI), National Research Council, Via P. Castellino 111, 80131 Naples, Italy.
Materias Srl, Corso N. Protopisani 50, 80146 Naples, Italy.
Gels. 2023 May 30;9(6):451. doi: 10.3390/gels9060451.
Polymeric materials have found increasing use in biomedical applications in the last decades. Among them, hydrogels represent the chosen class of materials to use in this field, in particular as wound dressings. They are generally non-toxic, biocompatible, and biodegradable, and they can absorb large amounts of exudates. Moreover, hydrogels actively contribute to skin repair promoting fibroblast proliferation and keratinocyte migration, allowing oxygen to permeate, and protecting wounds from microbial invasion. As wound dressing, -responsive systems are particularly advantageous since they can be active only in response to specific environmental (such as pH, light, ROS concentration, temperature, and glucose level). In this review, we briefly resume the human skin's structure and functions, as well as the wound healing phases; then, we present recent advances in -responsive hydrogels-based wound dressings. Lastly, we provide a bibliometric analysis of knowledge produced in the field.
在过去几十年中，高分子材料在生物医学应用中的使用越来越广泛。其中，水凝胶是该领域中首选的材料类别，特别是作为伤口敷料。它们通常无毒、具有生物相容性且可生物降解，并且能够吸收大量渗出液。此外，水凝胶通过促进成纤维细胞增殖和角质形成细胞迁移、允许氧气渗透以及保护伤口免受微生物入侵，积极助力皮肤修复。作为伤口敷料，响应型体系特别具有优势，因为它们仅能在特定的环境条件（如pH值、光、活性氧浓度、温度和葡萄糖水平）下发挥作用。在这篇综述中，我们简要概述了人类皮肤的结构和功能以及伤口愈合阶段；然后，我们介绍了基于响应型水凝胶的伤口敷料的最新进展。最后，我们对该领域产生的知识进行了文献计量分析。
