Grupcheva Christina N, Wong Tracey, Riley Andrew F, McGhee Charles N J
Discipline of Ophthalmology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Clin Exp Ophthalmol. 2002 Jun;30(3):187-90. doi: 10.1046/j.1442-9071.2002.00507.x.
The purpose of the study was to perform quantitative analysis of the sub-basal epithelial nerve plexus of healthy, living human cornea,using real time in vivo confocal microscopy and the analySIS software system. The study was based on in vivo confocalmicrostructural analysis of 50 eyes of 50 subjects, divided into two age groups: group 1 (n = 25)25 +/- 5 years of age, and group 2 (n = 25) 70 +/- 5 years of age. All subjects exhibited clinically healthy corneas. The overall nerve density was 632.35 +/- 287.57 microm/mm2 for group 1 and 582.39 +/- 327.13 microm/mm2 for group 2. The mean fibre dia-meter was measured at 0.52 +/- 0.23 microm for group 1 and at 0.56 +/- 0.27 microm for group 2. Beadings of the nerve fibres were recorded at a density of 213 +/- 123/mm for group 1 and 201 +/- 192/mm for group 2. Establishing standards for normal nerve density and morphology of the living human cornea at different ages may be beneficial, both in early detection and follow up of various corneal diseases and in post-surgical management following corneal surgery.
本研究的目的是使用实时体内共聚焦显微镜和分析软件系统，对健康活体人角膜的基底上皮下神经丛进行定量分析。该研究基于对50名受试者的50只眼睛进行的体内共聚焦微观结构分析，这些受试者被分为两个年龄组：第1组（n = 25），年龄为25 +/- 5岁；第2组（n = 25），年龄为70 +/- 5岁。所有受试者的角膜在临床上均表现健康。第1组的总体神经密度为632.35 +/- 287.57微米/平方毫米，第2组为582.39 +/- 327.13微米/平方毫米。第1组测量的平均纤维直径为0.52 +/- 0.23微米，第2组为0.56 +/- 0.27微米。第1组神经纤维的串珠状结构记录密度为213 +/- 123/毫米，第2组为201 +/- 192/毫米。建立不同年龄活体人角膜正常神经密度和形态的标准，可能对各种角膜疾病的早期检测和随访以及角膜手术后的手术管理都有益处。
