Martone Gianluca, Balestrazzi Alessandra, Ciprandi Giorgio, Balestrazzi Angelo
UOC Oculistica, Usl Sud-Est Toscana, Grosseto, Italy.
UOC Oculistica, ASL ROMA 2, Rome, Italy.
J Ophthalmol. 2022 Jun 7;2022:1951014. doi: 10.1155/2022/1951014. eCollection 2022.
Cataract surgery is widespread. The surgical procedure is associated with damage to the epithelial barrier and interruption of the corneal innervation. In addition, pathological events sustain signs and symptoms that may persist for a long time. Recently, a fixed combination of alpha-glycerylphosphorylcholine and D-Panthenol (Oftassiale) has been available as eye drops. The present study investigated the effects of an Oftassiale therapy in 20 patients undergoing cataract surgery. A comparison group included 20 patients treated with topical hyaluronic acid. Standard prophylactic and anti-inflammatory treatment was prescribed to all patients. Clinical signs and symptoms were assessed over time. In vivo confocal microscopy (IVCM) was performed accordingly. Oftassiale treatment significantly reduced clinical features and improved IVCM outcomes. In addition, therapy was well-tolerated, and no clinically significant adverse events occurred. In conclusion, this study confirmed that IVCM helps assess the tunnel after cataract surgery due to its ability to provide microscopic details in vivo. Topical therapy with alpha-glycerylphosphorylcholine and D-Panthenol eye drops promoted and stabilized the reepithelialization process. This fixed combination also accelerated and modulated the repair of the corneal innervation. Moreover, this treatment was well-tolerated and safe.
白内障手术很普遍。该手术过程会对上皮屏障造成损害并中断角膜神经支配。此外，病理事件会导致一些可能长期持续的体征和症状。最近，α-甘油磷酸胆碱和D-泛醇的固定组合（Oftassiale）已作为眼药水上市。本研究调查了Oftassiale疗法对20例接受白内障手术患者的影响。一个对照组包括20例接受局部透明质酸治疗的患者。所有患者均接受标准的预防性和抗炎治疗。随时间评估临床体征和症状。相应地进行了体内共聚焦显微镜检查（IVCM）。Oftassiale治疗显著减轻了临床症状并改善了IVCM结果。此外，该疗法耐受性良好，未发生具有临床意义的不良事件。总之，本研究证实，IVCM因其能够在体内提供微观细节，有助于评估白内障手术后的切口隧道。局部使用α-甘油磷酸胆碱和D-泛醇眼药水可促进并稳定角膜上皮再形成过程。这种固定组合还加速并调节了角膜神经支配的修复。此外，该治疗耐受性良好且安全。
