Barksdale Edward M, Stanford Ala
Intestinal Care Center, Department of Pediatric Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, 3705 Fifth Avenue, 4A-485, Pittsburgh, PA 15213, USA.
Curr Gastroenterol Rep. 2002 Jun;4(3):229-37. doi: 10.1007/s11894-002-0068-1.
Short bowel syndrome is a clinical entity that results from a diverse group of congenital and acquired conditions in the pediatric population. The pathophysiology of this syndrome is characterized by malabsorption, malnutrition, and metabolic disturbances. The vast majority of children with this condition undergo spontaneous adaptation of the intestinal remnant and achieve enteral nutritional autonomy. However, a small portion of pediatric patients develop intestinal failure and require long-term or permanent dependence on total parenteral nutrition. These children may benefit from surgical interventions that facilitate intestinal adaptation. Such adjunctive procedures facilitate nutrient absorption by improving motility, prolonging intestinal transit, and/or increasing mucosal contact time. In selected patients, this may allow them to be weaned from parenteral nutritional support or to have it discontinued. The purpose of this review is to discuss the various surgical techniques for the management of short bowel syndrome in children, along with their indications, complications, and outcomes.
短肠综合征是一种临床病症，由儿科人群中多种先天性和后天性疾病引起。该综合征的病理生理学特征为吸收不良、营养不良和代谢紊乱。绝大多数患有这种病症的儿童会经历肠道残余部分的自发适应，并实现肠内营养自主。然而，一小部分儿科患者会发展为肠衰竭，需要长期或永久依赖全肠外营养。这些儿童可能受益于促进肠道适应的手术干预。此类辅助手术通过改善蠕动、延长肠道运输时间和/或增加黏膜接触时间来促进营养吸收。在特定患者中，这可能使他们能够停止肠外营养支持或使其不再需要。本综述的目的是讨论治疗儿童短肠综合征的各种手术技术，以及它们的适应证、并发症和治疗结果。
