Neumann H J, Seyfarth H
Anat Anz. 1982;151(4):329-36.
It is found in the literature, that Centrophenoxine, an ester of Dimethylaminoethanol and p-Chlorphenoxyacetate, has a great influence on the increase in weight of embryos of Wistar-rats. In the light of the present researches on animals it is tested, if this adequate substance transformation effect of Centrophenoxine has a long lasting influence on the postnatal life, whereby the weight is considered as a parameter. Centrophenoxine was applied on the animals under test from 11-14 d post coitum that is during the time of embryogenesis. The test lasted over 5 generations. The animals were divided into 2 groups: In the first group Centrophenoxine was given to the first generation and the second to fifth generation of animals were paired each other; while in the other group each generation received this Centrophenoxine at the same time before birth. The weights of the young animals were taken at definite intervals and compared with that of the untreated control-animals as well as among themselves. The weight differences in the individual weighting times between the control and test groups were inconsiderable and were significant only in few cases. The results showed that Centrophenoxine applied prenatal has lost its weight increasing influence in the postnatal life. The reasons are discussed.
文献中发现，二甲氨基乙醇与对氯苯氧乙酸的酯类药物盐酸氯酯醒，对Wistar大鼠胚胎的体重增加有很大影响。根据目前对动物的研究，测试盐酸氯酯醒这种适当的物质转化作用是否对出生后的生活有长期影响，其中体重被视为一个参数。在交配后11 - 14天，即胚胎发生期，对受试动物施用盐酸氯酯醒。测试持续了5代。动物被分为两组：第一组中，第一代动物给予盐酸氯酯醒，第二代至第五代动物相互配对；而在另一组中，每一代动物在出生前同时接受这种盐酸氯酯醒。在一定间隔时间测量幼崽的体重，并与未处理的对照动物的体重以及它们自身之间的体重进行比较。对照组和测试组在各个称重时间的体重差异不显著，仅在少数情况下有统计学意义。结果表明，产前施用盐酸氯酯醒在出生后的生活中失去了其体重增加的影响。对原因进行了讨论。
