肝星状细胞激活的转录调控。
Transcriptional regulation of hepatic stellate cell activation.
作者信息
Mann D A, Smart D E
机构信息
Liver Group, Division of Infection, Inflammation, and Repair, University of Southampton, Southampton, UK.
出版信息
Gut. 2002 Jun;50(6):891-6. doi: 10.1136/gut.50.6.891.
Abstract
The hepatic stellate cell (HSC) is now well established as the key cellular element involved in the development of hepatic fibrosis and because of this there is considerable interest in establishing the molecular events that trigger and perpetuate HSC activation. HSC activation at the level of gene transcription requires the coordinated activity of several key transcriptional regulators of the HSC genome. The considerable advances that have been made in the past five years into the mechanisms by which specific families of transcription factors regulate the profibrogenic characteristics of the activated HSC are reviewed.
摘要
肝星状细胞（HSC）现已被确认为参与肝纤维化发展的关键细胞成分，正因如此，人们对确定触发和维持HSC激活的分子事件产生了浓厚兴趣。基因转录水平上的HSC激活需要HSC基因组的几个关键转录调节因子的协同作用。本文综述了过去五年在转录因子特定家族调控活化HSC促纤维化特性的机制方面取得的重大进展。
相似文献
1
Transcriptional regulation of hepatic stellate cell activation.肝星状细胞激活的转录调控。
Gut. 2002 Jun;50(6):891-6. doi: 10.1136/gut.50.6.891.
2
MicroRNA-101 suppresses liver fibrosis by targeting the TGFβ signalling pathway.MicroRNA-101 通过靶向 TGFβ 信号通路抑制肝纤维化。
J Pathol. 2014 Sep;234(1):46-59. doi: 10.1002/path.4373. Epub 2014 Jun 17.
3
Anti-adipogenic regulation underlies hepatic stellate cell transdifferentiation.抗脂肪生成调节是肝星状细胞转分化的基础。
J Gastroenterol Hepatol. 2006 Oct;21 Suppl 3:S102-5. doi: 10.1111/j.1440-1746.2006.04573.x.
4
The orphan nuclear receptor COUP-TFII coordinates hypoxia-independent proangiogenic responses in hepatic stellate cells.孤儿核受体 COUP-TFII 协调肝星状细胞中缺氧非依赖性的促血管生成反应。
J Hepatol. 2017 Apr;66(4):754-764. doi: 10.1016/j.jhep.2016.11.003. Epub 2016 Nov 17.
5
Activation of peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of curcumin on rat hepatic stellate cell growth.过氧化物酶体增殖物激活受体γ的激活有助于姜黄素对大鼠肝星状细胞生长的抑制作用。
Am J Physiol Gastrointest Liver Physiol. 2003 Jul;285(1):G20-30. doi: 10.1152/ajpgi.00474.2002. Epub 2003 Mar 26.
6
MicroRNA-155 attenuates activation of hepatic stellate cell by simultaneously preventing EMT process and ERK1 signalling pathway.微小RNA-155通过同时阻止上皮-间质转化过程和细胞外信号调节激酶1信号通路来减弱肝星状细胞的激活。
Liver Int. 2015 Apr;35(4):1234-43. doi: 10.1111/liv.12660. Epub 2014 Sep 15.
7
Regulation of E-box DNA binding during in vivo and in vitro activation of rat and human hepatic stellate cells.大鼠和人肝星状细胞体内及体外激活过程中E盒DNA结合的调控
Gut. 2001 Nov;49(5):713-9. doi: 10.1136/gut.49.5.713.
8
KLF2 exerts antifibrotic and vasoprotective effects in cirrhotic rat livers: behind the molecular mechanisms of statins.KLF2 在肝硬化大鼠肝脏中发挥抗纤维化和血管保护作用：他汀类药物的分子机制背后。
Gut. 2015 Sep;64(9):1434-43. doi: 10.1136/gutjnl-2014-308338. Epub 2014 Dec 10.
9
Characterization of the human zinc finger protein 267 promoter: essential role of nuclear factor Y.人类锌指蛋白267启动子的特性：核因子Y的重要作用
Biochim Biophys Acta. 2005 May 25;1729(1):14-23. doi: 10.1016/j.bbaexp.2005.03.001. Epub 2005 Mar 17.
10
SF-1 (steroidogenic factor-1), C/EBPbeta (CCAAT/enhancer binding protein), and ubiquitous transcription factors NF1 (nuclear factor 1) and Sp1 (selective promoter factor 1) are required for regulation of the mouse aldose reductase-like gene (AKR1B7) expression in adrenocortical cells.类固醇生成因子1（SF-1）、CCAAT增强子结合蛋白β（C/EBPβ）以及普遍存在的转录因子核因子1（NF1）和选择性启动子因子1（Sp1）是调节肾上腺皮质细胞中小鼠醛糖还原酶样基因（AKR1B7）表达所必需的。
Mol Endocrinol. 2001 Jan;15(1):93-111. doi: 10.1210/mend.15.1.0577.
引用本文的文献
1
Treatment of liver fibrosis in hepatolenticular degeneration with traditional Chinese medicine: systematic review of meta-analysis, network pharmacology and molecular dynamics simulation.中药治疗肝豆状核变性肝纤维化：Meta分析、网络药理学及分子动力学模拟的系统评价
Front Med (Lausanne). 2023 May 11;10:1193132. doi: 10.3389/fmed.2023.1193132. eCollection 2023.
2
Mitochondria-targeted curcumin loaded CTPP-PEG-PCL self-assembled micelles for improving liver fibrosis therapy.用于改善肝纤维化治疗的线粒体靶向姜黄素负载CTPP-PEG-PCL自组装胶束
RSC Adv. 2021 Jan 28;11(10):5348-5360. doi: 10.1039/d0ra09589c.
3
Paeoniflorin mitigates PBC-induced liver fibrosis by repressing NLRP3 formation.芍药苷通过抑制 NLRP3 形成缓解 PBC 诱导的肝纤维化。
Acta Cir Bras. 2022 Feb 18;36(11):e361106. doi: 10.1590/ACB361106. eCollection 2022.
4
Rho-Kinase as a Therapeutic Target for Nonalcoholic Fatty Liver Diseases.Rho-kinase 作为非酒精性脂肪性肝病的治疗靶点。
Diabetes Metab J. 2021 Sep;45(5):655-674. doi: 10.4093/dmj.2021.0197. Epub 2021 Sep 30.
5
N-n-Butyl haloperidol iodide ameliorates liver fibrosis and hepatic stellate cell activation in mice.正丁基卤化氢哌啶改善小鼠肝纤维化和肝星状细胞活化。
Acta Pharmacol Sin. 2022 Jan;43(1):133-145. doi: 10.1038/s41401-021-00630-7. Epub 2021 Mar 23.
6
Updates in the quantitative assessment of liver fibrosis for nonalcoholic fatty liver disease: Histological perspective.非酒精性脂肪性肝病肝纤维化定量评估的研究进展：组织学视角。
Clin Mol Hepatol. 2021 Jan;27(1):44-57. doi: 10.3350/cmh.2020.0181. Epub 2020 Nov 19.
7
Antigen presentation, autoantibody production, and therapeutic targets in autoimmune liver disease.自身免疫性肝病中的抗原呈递、自身抗体产生和治疗靶点。
Cell Mol Immunol. 2021 Jan;18(1):92-111. doi: 10.1038/s41423-020-00568-6. Epub 2020 Oct 27.
8
Integrative omics analysis identifies macrophage migration inhibitory factor signaling pathways underlying human hepatic fibrogenesis and fibrosis.整合组学分析确定了人类肝纤维化和纤维化背后的巨噬细胞迁移抑制因子信号通路。
J BioX Res. 2019 Mar;2(1):16-24. doi: 10.1097/jbr.0000000000000026.
9
Myocardin and myocardin-related transcription factor-A synergistically mediate actin cytoskeletal-dependent inhibition of liver fibrogenesis.肌球蛋白结合转录因子 A 与肌球蛋白相关转录因子 A 协同介导肌动蛋白细胞骨架依赖性的肝纤维化抑制。
Am J Physiol Gastrointest Liver Physiol. 2020 Mar 1;318(3):G504-G517. doi: 10.1152/ajpgi.00302.2019. Epub 2020 Jan 13.
10
Dual TBK1/IKKɛ inhibitor amlexanox attenuates the severity of hepatotoxin-induced liver fibrosis and biliary fibrosis in mice.双 TBK1/IKKɛ 抑制剂氨来呫诺能减轻小鼠肝毒素诱导的肝纤维化和胆管纤维化的严重程度。
J Cell Mol Med. 2020 Jan;24(2):1383-1398. doi: 10.1111/jcmm.14817. Epub 2019 Dec 10.
本文引用的文献
1
Regulation of E-box DNA binding during in vivo and in vitro activation of rat and human hepatic stellate cells.大鼠和人肝星状细胞体内及体外激活过程中E盒DNA结合的调控
Gut. 2001 Nov;49(5):713-9. doi: 10.1136/gut.49.5.713.
2
Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats.Gliotoxin刺激人和大鼠肝星状细胞的凋亡，并增强大鼠肝纤维化的消退。
Gastroenterology. 2001 Sep;121(3):685-98. doi: 10.1053/gast.2001.27188.
3
Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificity.多种亲密接触：介导转录调控特异性的Fos-Jun相互作用
Oncogene. 2001 Apr 30;20(19):2438-52. doi: 10.1038/sj.onc.1204385.
4
AP-1 in cell proliferation and survival.细胞增殖与存活中的活化蛋白-1
Oncogene. 2001 Apr 30;20(19):2390-400. doi: 10.1038/sj.onc.1204383.
5
The mammalian Jun proteins: redundancy and specificity.哺乳动物的Jun蛋白：冗余性与特异性
Oncogene. 2001 Apr 30;20(19):2378-89. doi: 10.1038/sj.onc.1204381.
6
Jun, the oncoprotein.原癌蛋白Jun。
Oncogene. 2001 Apr 30;20(19):2365-77. doi: 10.1038/sj.onc.1204443.
7
Peroxisome proliferator-activated receptor gamma and metabolic disease.过氧化物酶体增殖物激活受体γ与代谢性疾病
Annu Rev Biochem. 2001;70:341-67. doi: 10.1146/annurev.biochem.70.1.341.
8
CD40 activates NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells.CD40激活核因子-κB和c-Jun氨基末端激酶，并增强活化的人肝星状细胞上趋化因子的分泌。
J Immunol. 2001 Jun 1;166(11):6812-9. doi: 10.4049/jimmunol.166.11.6812.
9
JunD regulates transcription of the tissue inhibitor of metalloproteinases-1 and interleukin-6 genes in activated hepatic stellate cells.JunD调节活化肝星状细胞中金属蛋白酶组织抑制剂-1和白细胞介素-6基因的转录。
J Biol Chem. 2001 Jun 29;276(26):24414-21. doi: 10.1074/jbc.M101840200. Epub 2001 May 3.
10
Myofibroblasts: molecular crossdressers.
Curr Top Dev Biol. 2001;51:91-107. doi: 10.1016/s0070-2153(01)51003-0.
Zotero 插件