Mann D A, Smart D E
Liver Group, Division of Infection, Inflammation, and Repair, University of Southampton, Southampton, UK.
Gut. 2002 Jun;50(6):891-6. doi: 10.1136/gut.50.6.891.
The hepatic stellate cell (HSC) is now well established as the key cellular element involved in the development of hepatic fibrosis and because of this there is considerable interest in establishing the molecular events that trigger and perpetuate HSC activation. HSC activation at the level of gene transcription requires the coordinated activity of several key transcriptional regulators of the HSC genome. The considerable advances that have been made in the past five years into the mechanisms by which specific families of transcription factors regulate the profibrogenic characteristics of the activated HSC are reviewed.
肝星状细胞（HSC）现已被确认为参与肝纤维化发展的关键细胞成分，正因如此，人们对确定触发和维持HSC激活的分子事件产生了浓厚兴趣。基因转录水平上的HSC激活需要HSC基因组的几个关键转录调节因子的协同作用。本文综述了过去五年在转录因子特定家族调控活化HSC促纤维化特性的机制方面取得的重大进展。
