Shubitz L F, Matz M E, Noon T H, Reggiardo C C, Bradley G A
Department of Veterinary Science and Microbiology, College of Agriculture and Life Sciences, University of Arizona, Tucson 85721, USA.
J Am Vet Med Assoc. 2001 Feb 15;218(4):537-40, 526. doi: 10.2460/javma.2001.218.537.
A 4-year-old castrated male mixed-breed dog with a history of coccidioidomycosis was referred for evaluation of abdominal and pleural effusion. Results of radiography, ultrasonography, cytologic evaluation of thoracic fluid, and serologic testing supported a diagnosis of constrictive pericarditis secondary to infection with Coccidioides immitis. Aggressive treatment for presumptive coccidioidomycosis was begun, but the dog's condition continued to deteriorate, and the dog was euthanatized. At necropsy, the pericardium was thicker than normal and fibrotic and adhered to the epicardium. Microscopically, the pericardium and 1 section of epicardium contained lymphoplasmacytic infiltrates with a few macrophages and neutrophils. Coccidioides immitis was cultured from pericardial fluid. A search of records from the Arizona Veterinary Diagnostic Laboratory for 1988 through 1998 revealed that of 46 dogs in which a diagnosis of coccidioidomycosis was confirmed at necropsy, 13 had involvement of the heart or pericardium.
一只4岁去势的雄性混血犬，有球孢子菌病病史，因腹腔和胸腔积液前来评估。放射学、超声检查、胸水细胞学评估和血清学检测结果支持诊断为球孢子菌感染继发的缩窄性心包炎。开始对疑似球孢子菌病进行积极治疗，但犬的病情持续恶化，最终实施安乐死。尸检时，心包比正常厚且纤维化，并与心外膜粘连。显微镜下，心包和部分心外膜有淋巴细胞和浆细胞浸润，伴有少量巨噬细胞和中性粒细胞。心包液培养出球孢子菌。查阅亚利桑那兽医诊断实验室1988年至1998年的记录发现，在尸检确诊为球孢子菌病的46只犬中，有13只心脏或心包受累。
