Bondjers G, Björkerud S
Atherosclerosis. 1975 Nov-Dec;22(3):379-87. doi: 10.1016/0021-9150(75)90018-0.
During incubation of normal arterial tissue with serum lipoproteins, net transfer of cholesterol was observed in the direction from the lipoproteins into the arterial tissue. Such transfer was only observed during incubations with single, isolated lipoprotein fractions. It was independent of the type of lipoprotein, VLDL, LDL or HDL, which was incubated with the arterial tissue. On the other hand, no net transfer of cholesterol was observed during incubations of arterial tissue with a combination of serum lipoproteins equivalent to that in native serum. Studies on the transfer of radioactive cholesterol suggested that cholesterol elimination from arterial tissue in vitro was not affected by the composition of the incubation medium. Therefore, it is suggested that cholesterol accumulation more easily is influenced by the serum lipoprotein composition, and that serum lipoprotein dysbalance may promote cholesterol accumulation in the tissue. This effect may be present even when the dysbalance involves a decrease of specific serum lipoprotein fractions.
在正常动脉组织与血清脂蛋白孵育过程中，观察到胆固醇的净转移方向是从脂蛋白进入动脉组织。这种转移仅在与单一分离的脂蛋白组分孵育时观察到。它与与动脉组织孵育的脂蛋白类型（极低密度脂蛋白、低密度脂蛋白或高密度脂蛋白）无关。另一方面，在动脉组织与相当于天然血清中脂蛋白组合孵育时，未观察到胆固醇的净转移。对放射性胆固醇转移的研究表明，体外动脉组织中胆固醇的消除不受孵育培养基组成的影响。因此，有人提出胆固醇积累更容易受到血清脂蛋白组成的影响，血清脂蛋白失衡可能促进组织中胆固醇的积累。即使这种失衡涉及特定血清脂蛋白组分的减少，这种效应也可能存在。
