Fellin R, Briani G, Balestrieri P, Baggio G, Baiocchi M R, Crepaldi G
Atherosclerosis. 1975 Nov-Dec;22(3):431-45. doi: 10.1016/0021-9150(75)90023-4.
Results related to long term treatment with Colestipol (a new resin sequestering bile acids) in 23 subjects with familial hypercholesterolaemia, 12 with Type IIA, 8 with Type IIB and 3 homozygotes are reported. Patients were given 15 g/day active drug for a period of 12 months and a double dose (30 g/day) for a successive period of 4 months along with a low cholesterol, low saturated fat, polyunsaturated fat-rich diet. Mean cholesterol decrease was --42 +/- 18 mg/dl (P less than 0.05) after 12 months of 15 g/day Colestipol and --69 +/- 17 mg/dl (P less than 0.01) after the following 4 months of 30 g/day Colestipol. The difference between the two periods of treatment (15 g and 30 g/day was not statistically significant. A slight but not significant increase in triglyceride levels was observed. Serum uric acid showed a significant increase throughout the entire period of treatment. No malabsorption syndrome or signs of toxicity were seen. Most frequent side effects were constipation, nausea, and metheorism which, with the exception of 4 cases which were withdrawn from the study, were reported as being transitory and mild.
报告了23例家族性高胆固醇血症患者长期使用考来替泊（一种新型胆汁酸螯合树脂）治疗的结果，其中12例为IIA型，8例为IIB型，3例为纯合子。患者每天服用15克活性药物，持续12个月，随后连续4个月服用双倍剂量（30克/天），同时搭配低胆固醇、低饱和脂肪、富含多不饱和脂肪的饮食。每天服用15克考来替泊12个月后，平均胆固醇降低了-42±18毫克/分升（P<0.05），随后每天服用30克考来替泊4个月后，平均胆固醇降低了-69±17毫克/分升（P<0.01）。两个治疗阶段（15克/天和30克/天）之间的差异无统计学意义。观察到甘油三酯水平有轻微但不显著的升高。在整个治疗期间，血清尿酸显著升高。未观察到吸收不良综合征或毒性迹象。最常见的副作用是便秘、恶心和胃肠胀气，除4例退出研究的病例外，其余均报告为短暂且轻微。
