Parodi A, Caproni M, Marzano A V, De Simone C, La Placa M, Quaglino P, Veller Fornasa C, Zane C, Vaccaro M, Papini M, Fabbri P, Rebora A
Department of Endocrinological and Metabolic Diseases, University of Genoa, Genova, Italy.
Acta Derm Venereol. 2002;82(1):48-51. doi: 10.1080/000155502753600894.
We retrospectively studied 132 patients with dermatomyositis; 84 had idiopathic, 30 paraneoplastic, 5 juvenile and 13 amyopathic forms of the disease. The commonest features were macular erythema, heliotropic erythema and Gottron's papules. Flagellate erythema occurred in 5% of patients with idiopathic dermatomyositis and correlated with the disease activity. Necrotic lesions were also found in this group of patients but did not always signal malignancy. The prevalence of malignancy was high (23%). Raynaud's phenomenon occurred in 10.6% of patients, also in those with malignancy. Dysphagia, interstitial lung disease and arthralgias affected 20%, 8% and 40% of patients, respectively. Anti-Jo-1 antibodies were found in 5% of patients with idiopathic dermatomyositis and low titre ANA in 1/3 of patients. ANA did not correlate with the disease activity. We confirmed the data from the literature, but no cutaneous sign, constitutional symptom or circulating antibody was found marking a particular subtype of the disease.
我们对132例皮肌炎患者进行了回顾性研究；其中84例为特发性，30例为副肿瘤性，5例为青少年型，13例为无肌病型。最常见的特征是斑状红斑、向阳疹和Gottron丘疹。鞭状红斑出现在5%的特发性皮肌炎患者中，且与疾病活动相关。在这组患者中也发现了坏死性病变，但并不总是提示恶性肿瘤。恶性肿瘤的患病率很高（23%）。雷诺现象出现在10.6%的患者中，恶性肿瘤患者也有出现。吞咽困难、间质性肺病和关节痛分别影响20%、8%和40%的患者。5%的特发性皮肌炎患者发现有抗Jo-1抗体，1/3的患者ANA滴度较低。ANA与疾病活动无关。我们证实了文献中的数据，但未发现可标记该疾病特定亚型的皮肤体征、全身症状或循环抗体。
