Hara Kazuya, Shimada Akinori, Morita Takehito, Sawada Masumi, Umemura Takashi
Department of Veterinary Pathology, Tottori University, Japan.
J Vet Med Sci. 2002 Apr;64(4):391-3. doi: 10.1292/jvms.64.391.
A case of olfactory neuroepithelioma was investigated electron microscopically and immunohistochemically. The tumor mass was found in the nasal cavities of a 10-year-old female dog, which showed epistaxis, nasal discharge and facial swelling. The tumor tissue consisted of tubular structure of cuboidal to columnar cells and compactly arranged nests of small cells surrounded by a fibrovascular stroma. Mitotic figures were frequently observed. Immunohistochemically, the tumor cells frequently showed positive for neurofilament protein, synaptophysin and/or carnosine in addition to keratin. Ultrastructurally, tight junction was observed between the tumor cells. No dense-cored secretory granules were shown in the tumor cells. These findings indicated that the present tumor had neuronal and epithelial features probably originating from the olfactory epithelium.
对一例嗅神经上皮瘤进行了电子显微镜和免疫组织化学研究。肿瘤块发现于一只10岁雌性犬的鼻腔，该犬表现出鼻出血、鼻分泌物和面部肿胀。肿瘤组织由立方状至柱状细胞的管状结构以及紧密排列的小细胞巢组成，周围有纤维血管基质。频繁观察到有丝分裂象。免疫组织化学显示，除角蛋白外，肿瘤细胞还经常对神经丝蛋白、突触素和/或肌肽呈阳性。超微结构上，在肿瘤细胞之间观察到紧密连接。肿瘤细胞中未显示有致密核心分泌颗粒。这些发现表明，目前的肿瘤具有可能起源于嗅上皮的神经元和上皮特征。
