Geller Barbara, Zimerman Betsy, Williams Marlene, Delbello Melissa P, Frazier Jeanne, Beringer Linda
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA.
J Child Adolesc Psychopharmacol. 2002 Spring;12(1):3-9. doi: 10.1089/10445460252943524.
Children are developmentally incapable of many manifestations of bipolar symptoms described in adults (e.g., children do not "max" out credit cards or have four marriages). To address this issue, our group investigated prepubertal and early adolescent age equivalents of adult mania behaviors.
Details of the methods appear in the companion article in this issue (Geller et al. 2002a). Subjects had a prepubertal and early adolescent bipolar disorder phenotype (PEA-BP) that was validated by reliable assessment (Geller et al. 2001b), 6-month stability (Geller et al. 2000c), and 1- and 2-year longitudinal diagnostic outcome (Geller et al. 2001a, 2002b).
Examples of elation, grandiosity, decreased need for sleep, racing thoughts, and hypersexuality in PEA-BP subjects were compared to examples in prepubertal normal controls and to examples in late teenage/adult-onset mania. Because it is not intuitive that children can be pathologically happy or expansive, sections on guidelines for differentiating normal versus impairing elation and grandiosity are provided.
Due to the high comorbidity of PEA-BP and attention deficit hyperactivity disorder (ADHD), recognition of mania symptoms that do not overlap with those for ADHD may aid in avoiding both under- and overdiagnosis of child bipolar disorder. A discussion of how "nonoverlapping with ADHD" Diagnostic and Statistical Manual of Mental Disorders (4th ed.) mania symptoms can be useful in the differential diagnosis of irritability is also provided.
儿童在发育上无法表现出成人双相情感障碍症状的许多表现(例如,儿童不会刷爆信用卡或经历四次婚姻)。为解决这一问题,我们团队研究了青春期前和青春期早期与成人躁狂行为相当的表现。
方法的详细内容见本期的配套文章(盖勒等人,2002a)。受试者具有青春期前和青春期早期双相情感障碍表型(PEA - BP),该表型已通过可靠评估(盖勒等人,2001b)、6个月稳定性(盖勒等人,2000c)以及1年和2年纵向诊断结果(盖勒等人,2001a,2002b)得到验证。
将PEA - BP受试者的欣快、夸大、睡眠需求减少、思维奔逸和性欲亢进的例子与青春期前正常对照组的例子以及青少年晚期/成人期起病躁狂的例子进行了比较。由于儿童可能出现病理性欣快或夸大并不直观,因此提供了区分正常欣快与病理性欣快以及正常夸大与病理性夸大的指南部分。
由于PEA - BP与注意力缺陷多动障碍(ADHD)的高共病率,识别与ADHD不重叠的躁狂症状可能有助于避免儿童双相情感障碍的漏诊和误诊。还讨论了《精神障碍诊断与统计手册》(第4版)中“与ADHD不重叠”的躁狂症状在易激惹鉴别诊断中的作用。