Duke P C, Fung H, Gartner J
Can Anaesth Soc J. 1975 Nov;22(6):680-6. doi: 10.1007/BF03013316.
The effect of pancuronium on myocardial contractility was studied in three different animal preparations. Pancuronium produced no change in isometric contraction of rabbit atrial or cat papillary muscle but displaced the acetylcholine dose-response curve to the right in the papillary muscle preparations, verifying a muscarinic blocking effect of this drug. In atropinized dogs in vivo pancuronium produced no significant change in the cardiovascular parameters studied. These studies show that pancuronium exerts its cardiovascular effects primarily by blocking muscarinic receptors in the heart.
在三种不同的动物实验准备中研究了泮库溴铵对心肌收缩力的影响。泮库溴铵对兔心房或猫乳头肌的等长收缩没有影响，但在乳头肌实验准备中使乙酰胆碱剂量反应曲线右移，证实了该药物的毒蕈碱阻断作用。在体内已用阿托品处理的犬中，泮库溴铵对所研究的心血管参数没有显著影响。这些研究表明，泮库溴铵主要通过阻断心脏中的毒蕈碱受体发挥其心血管作用。
