哌库溴铵和泮库溴铵对离体兔心脏的作用。

Effects of pipecuronium and pancuronium on the isolated rabbit heart.

作者信息

Deam R K, Soni N

机构信息

Anaesthetic Department, Royal Free Hospital, Hampstead, London.

出版信息

Br J Anaesth. 1989 Mar;62(3):287-9. doi: 10.1093/bja/62.3.287.

DOI:10.1093/bja/62.3.287

PMID:2564784

Abstract

We have studied the effects of pipecuronium and pancuronium on myocardial contractility and heart rate in two different animal preparations. Pipecuronium and pancuronium produced no change in isometric contraction of rabbit atria. The chronotropic effects of pipecuronium, pancuronium and vecuronium were investigated using acetylcholine as an agonist in isolated perfused rabbit heart. Pancuronium but not pipecuronium or vecuronium, produced a significant degree of antagonism to the bradycardia produced by acetylcholine.

摘要

我们在两种不同的动物制剂中研究了哌库溴铵和泮库溴铵对心肌收缩力和心率的影响。哌库溴铵和泮库溴铵对兔心房的等长收缩无影响。在离体灌注兔心脏中，以乙酰胆碱作为激动剂，研究了哌库溴铵、泮库溴铵和维库溴铵的变时作用。泮库溴铵对乙酰胆碱所致的心动过缓产生了显著程度的拮抗作用，而哌库溴铵和维库溴铵则没有。