Gajalakshmi Vendhan, Peto Richard, Kanaka Santhanakrishnan, Balasubramanian Sivagurunathan
Division of Epidemiology, Cancer Institute (WIA), Chennai, India.
BMC Public Health. 2002 May 16;2:7. doi: 10.1186/1471-2458-2-7.
In the city of Chennai, India, registration of the fact of death is almost complete but the cause of death is often inadequately recorded on the death certificate. A special verbal autopsy (VA) study of 48 000 adult deaths in Chennai during 1995-97 was conducted to arrive at the probable underlying cause of death and to measure cause specific mortality rates for Chennai.
Trained non-medical graduates with at least 15 years of formal education interviewed the surviving family members or an associate of the deceased to write a report on the complaints, symptoms, signs, duration and treatment details of illness prior to death. Each report was reviewed centrally by two physicians independently. The reliability was assessed by comparing deaths attributed to cancer by VA with records in Vital Statistics Department and Chennai Cancer Registry.
The VA reduced the proportion of deaths attributed to unspecified medical causes and unknown causes from 37% to 7% in early adult life and middle age (25-69 yrs) and has yielded fewer unspecified causes (only 10%) than the death certificate. The sensitivity of VA to identify cancer was 94% in the age group 25-69.
VA is practicable for deaths in early adult life or middle age and is of more limited value in old age. A systematic program of VA of a representative sample of deaths could assign broad causes not only to deaths in childhood (as has previously been established) but also to deaths in early adult life and middle age.
在印度金奈市,死亡事实登记几乎完备,但死亡原因在死亡证明上的记录往往不充分。1995 - 1997年期间对金奈市48000例成人死亡病例进行了一项特殊的口头尸检(VA)研究,以确定可能的潜在死亡原因,并测算金奈市特定病因的死亡率。
由受过培训、至少接受过15年正规教育的非医学专业毕业生,对在世的家庭成员或死者的一位亲友进行访谈,以撰写一份关于死者生前疾病的症状、体征、患病时长及治疗细节的报告。每份报告由两名医生独立进行集中审核。通过将VA认定为癌症导致的死亡病例与生命统计部门及金奈癌症登记处的记录进行比较,评估其可靠性。
在成年早期和中年(25 - 69岁),VA将归因于未明确医学病因和不明原因的死亡比例从37%降至7%,且与死亡证明相比,未明确病因的比例更低(仅10%)。在25 - 69岁年龄组中,VA识别癌症的敏感度为94%。
VA适用于成年早期或中年的死亡病例,对老年病例的价值较为有限。一项对具有代表性的死亡样本进行VA的系统性计划,不仅可以为儿童期死亡(如先前已证实的)确定大致病因,还可为成年早期和中年死亡确定病因。